Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles

Bellam, Mahesh; Gundluru, Mohan; Sarva, Santhisudha; Sridevi, C.; Netala, Vasudeva Reddy; Vijaya, Tartte; Cirandur, Suresh Reddy

doi:10.1007/s10593-017-2036-6

Cited by 29 publications

(18 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The extended resonance produced by the radical formed from the benzyl group during the reaction may help in enhancing DPPH scavenging ability of the compounds. 43…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Evaluation of Analgesic and Antioxidant Activities of Substituted Benzimidazole Derivatives

Brishty

Saha

Mahmud

et al. 2020

Dhaka Univ. J. Pharm. Sci

View full text Add to dashboard Cite

The present study describes the synthesis and pharmacological evaluation of a number of substituted benzimidazole derivatives designated by 3A-1, 3A-2, 3A-3, 3B-1 and 3B-2 through condensation of different o-aryldiamine compounds with the corresponding aldehyde employing ammonium salt as a catalyst. All the compounds were characterized by IR and 1H NMR spectroscopic analysis. The synthesized benzimidazole derivatives were investigated for analgesic and antioxidant activities using acetic acid-induced writhing inhibition in Swiss albino mice and DPPH free radical scavenging assay, respectively. Compounds 3A-3, 3B-1 and 3B-2 at a dose of 50 mg/kg body weight reduced the number of writhings by 88.24%, 84.03% and 85.71%, respectively (p<0.001) in comparison with standard diclofenac (90.76% inhibition). The derivatives 3A-1, 3A-2, 3A-3 and 3B-2 showed prominent antioxidant activity with IC50 values of 0.038, 0.959, 8.834 and 7.519 μg/ml, respectively in comparison with the standard butylated hydroxytoluene (BHT) (14.44 μg/ml). Among the synthesized compounds, 3A-3 and 3B- 2 emerged as the most promising analgesic and antioxidant agents and expressed their potential as lead compounds in future research. Dhaka Univ. J. Pharm. Sci. 19(1): 37-46, 2020 (June)

show abstract

“…The extended resonance produced by the radical formed from the benzyl group during the reaction may help in enhancing DPPH scavenging ability of the compounds. 43…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Evaluation of Analgesic and Antioxidant Activities of Substituted Benzimidazole Derivatives

Brishty

Saha

Mahmud

et al. 2020

Dhaka Univ. J. Pharm. Sci

View full text Add to dashboard Cite

show abstract

“…Among a library of N -substituted pyrazole-containing benzimidazoles, compounds 202 – 204 attributed prominent antioxidant activity in both DPPH and hydrogen peroxide assay supposed to the presence of benzyl substituent on imidazole nitrogen ( Bellam et al, 2017 ). Besides, Anastassova et al ( Anastassova et al, 2018a ) evaluated antioxidant property of compounds 205–206 using tert-butyl hydroperoxide ( tert -BOOH) induced oxidative stress on rat hepatocytes, and reported that both compounds showed significant effect comparable to standard quercetin.…”

Section: Biological Activitiesmentioning

confidence: 99%

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

et al. 2021

View full text Add to dashboard Cite

Nowadays, nitrogenous heterocyclic molecules have attracted a great deal of interest among medicinal chemists. Among these potential heterocyclic drugs, benzimidazole scaffolds are considerably prevalent. Due to their isostructural pharmacophore of naturally occurring active biomolecules, benzimidazole derivatives have significant importance as chemotherapeutic agents in diverse clinical conditions. Researchers have synthesized plenty of benzimidazole derivatives in the last decades, amidst a large share of these compounds exerted excellent bioactivity against many ailments with outstanding bioavailability, safety, and stability profiles. In this comprehensive review, we have summarized the bioactivity of the benzimidazole derivatives reported in recent literature (2012–2021) with their available structure-activity relationship. Compounds bearing benzimidazole nucleus possess broad-spectrum pharmacological properties ranging from common antibacterial effects to the world’s most virulent diseases. Several promising therapeutic candidates are undergoing human trials, and some of these are going to be approved for clinical use. However, notable challenges, such as drug resistance, costly and tedious synthetic methods, little structural information of receptors, lack of advanced software, and so on, are still viable to be overcome for further research.

show abstract

“…Their therapeutic usages include anticancer, [ 5 ] antifungal, [ 6 ] antibacterial, [ 7 ] anti‐inflammatory, [ 8 ] and antioxidant. [ 9 ] They have applications in the field of veterinary products, agrochemicals, corrosion inhibitors, developers, copolymers and so on. [ 10,11 ]…”

Section: Introductionmentioning

confidence: 99%

An overview of palladium‐catalyzed synthesis of seven‐membered heterocycles

Saranya

Neetha

Radhika

et al. 2020

Journal of Heterocyclic Chem

View full text Add to dashboard Cite

Heterocyclic compounds are the ones that have always remained in the limelight owing to their superior contributions toward various disciplines such as biology, medicine, material science, pharmaceutical science, industry and so on. They form the building blocks of DNA and RNA macromolecules. Suitable tuning of these heterocyclic compounds can result in chemotherapeutic moieties with superlative efficiency. Seven‐membered heterocyclic compounds are an important class of heterocyclic chemistry. Some of them are azepine, oxepine, thiepine, diazepine, thiazepine and so on. Transition metal‐catalyzed synthesis of heterocycles has been the most explored in the recent past. Palladium is known as the best suitable catalyst for the same and that is the result of its excellent functional group tolerance and catalytic potency. Here, we intend to summarize the various investigations made on the palladium‐catalyzed synthesis of seven‐membered heterocycles. To the best of our knowledge, this is the first review in this topic and covers literature up to 2020.

show abstract

Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles

Cited by 29 publications

References 21 publications

Synthesis and Evaluation of Analgesic and Antioxidant Activities of Substituted Benzimidazole Derivatives

Synthesis and Evaluation of Analgesic and Antioxidant Activities of Substituted Benzimidazole Derivatives

A Comprehensive Account on Recent Progress in Pharmacological Activities of Benzimidazole Derivatives

An overview of palladium‐catalyzed synthesis of seven‐membered heterocycles

Contact Info

Product

Resources

About