Synthesis and antioxidant properties of some new thiazolyl coumarin derivatives

Abstract

A three-component one-pot synthesis of new thiazolyl coumarin derivatives was carried out by condensing 3-acetyl-4-hydroxycoumarin, arylaldehydes, thiourea and ammonium acetate at reflux in DMC. The optimization details of the developed novel protocol are recorded. In addition, we have also synthesized these compounds via another second route in two steps. High atom-economy, excellent yields, simple procedure, and mild reaction conditions are the important features of this one-pot protocol. The chemical structures of the newly synthesized compounds were elucidated by using analytical (IR, 1 H NMR, 13 C NMR). Further, all the compounds were screened for their antioxidant activities.

Synthesis and Biological Properties of Coumarin Derivatives. A Review

“…Recently, significant progress has been made in the biological activities of coumarin compounds and their derivatives, which are considered a fundamental class of bioactive molecules, due to their use in several biological systems and in pharmaceuticals. Some of these biological activities are summarized in the [108] A. Witaicenis et al [109] F. Li et al [110] D. Bensalah et al [111] Y.K. Al-Majedy et al [112] Antiproliferative L. Saso et al [113] E. Schwiebert et al [114] M.K.…”

Novel synthesis of 3-(Phenyl) (ethylamino) methyl)-4-hydroxy-2H-chromen-2-one derivatives using biogenic ZnO nanoparticles and their applications

“…The 4H-pyran core is a rich source of biologically vital molecules possessing a broad spectrum of biological and pharmacological activities [7]. Pharmacological activities includes neuroprotective agents [8], antimicrobial agents [9,10], cardio preventive agents [11], antioxidant [12][13][14], anti-inflammatory agents [15] and antituberculating agents [16]. Further, the presence of N and O made them good corrosive inhibitors [17,18].…”

In Vitro Bioactivities of Isoindolin-1-3-Phosophonate Compounds

“…As part of our interest to develop a practical and e cient synthesis method in an environmentally friendly manner [45][46][47], we herein report an alternative, simple route for the synthesis of isoindolin-1-one-3phosphonates 4. Furthermore, these compounds were investigated for their antimicrobial activity against Micrococcus luteus, Listeria monocytogenes, Staphylococcus aureus, Bacillus cereus, Salmonella typhimurium and Candida albicans and for their anti-parasitical activity against Leishmania major and Toxoplasam gondii.…”