Synthesis and antioxidant study of new hydrazones derived from bisdemethoxycurcumin pyrazole

Abstract

The antioxidant activity of new hydrazones derived from bisdemethoxycurcumin pyrazole was investigated. The study was divided into two main parts: The first one includes the synthesis and characterization of the target compounds from bisdemethoxycurcumin (BDMC), while the second step is devoted to the investigation of their antioxidant activities. In the first step of synthesis, the curcumin-pyrazole (2) was synthesized by the reaction of BDMC with hydrazine hydrate. Later, the obtained product treated with ethyl 2chloroacetate to produce curcumine ester (3), then the product was converted to hydrazide (4) by the reaction of curcumin ester (3) with hydrazine hydrate. Finally, curcumine hydrazones (5a-f) were synthesized from the reaction of hydrazide (4) with substituted aromatic aldehydes. All compounds were characterized with the aid of suitable spectroscopic techniques. The antioxidant activity of the prepared compounds was studied against the stable radical α,α-diphenyl-β-picrylhydrazyl. The study showed that only the phenolic OHcontaining compounds (2, 5b and 5f) have antioxidant activity.

Synthesis, optical nonlinear properties, and all‐optical switching of curcumin analogues

“…[51][52][53][54][55][56][57][58] Our continuous search for curcumin and its compounds is due to the functional value of these biomolecules in pharmaceutical, medicinal, biophysical, and bioorganic chemistry with pronounced physiological activities. [33,36,59] Curcumin was studied in a number of scientific applications. [60][61][62] We have been engaged in the period 2018-2020 in the study and improve the nonlinear properties of bisdemethoxycurcumin, [63] curcumin, dimethoxycurcumin, chlorocurcumin, [64] alphamethyl curcumin: PMMA film using gamma radiation, [65] and two dihydropyridones derived from curcumin.…”

Design and Synthesis of New Curcuminoid Compounds and their Derivatives as Antioxidant Agents

“…These problems can be addressed by the modification of curcumin [14,15]. For decades, the researchers have been trying to design and synthesize super curcumin from curcumin derivatives and their analogues [16,17].…”

Synthesis and antioxidant evaluation for monocarbonyl curcuminoids and their derivatives

“…Curcumine is a natural extract from rhizome of curcumine longa (Turmeric) (1) The pigment yellow color of extracted contained three isomers of curcuminoids (curcumine, demethoxy curcumine and bis demethoxy curcumine) (2) . This natural compound has been used as food pigment and in food industries (3) .…”