Synthesis and antiphospholipase activity of 3,5-disubstituted thiotetronic acid derivatives

Rubinov, D. B.; Zheldakova, T. A.; Rubinova, I. L.; Kuchuro, S. V.; Babitskaya, S. V.; Rakhuba, G. N.; Litvinko, N. M.

doi:10.1134/s1070428006030146

Russ J Org Chem

2006

DOI: 10.1134/s1070428006030146

|View full text |Cite

Synthesis and antiphospholipase activity of 3,5-disubstituted thiotetronic acid derivatives

D. B. Rubinov

T. A. Zheldakova

I. L. Rubinova

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2006

2011

Publication Types

Select...

Article2

Relationship

Self Cite1

Independent1

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An exception from the above series was 3-acetylthiotetronic acid which reacted with aromatic aldehydes under the conditions of both basic and acid catalysis at the endocyclic methylene group [10]. In the presence of excess aldehyde the condensation involved both reaction centers [11].…”

mentioning

confidence: 99%

Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

2011

Self Cite

View full text Add to dashboard Cite

Condensation of 2-acetylcyclohexane-1,3-diones with aromatic aldehydes in the presence of piperidine, pyrrolidine, hexamethyleneimine, or morpholine gave the corresponding 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones as the major products and 2-[3-aryl-1-cycloalkylaminoprop-2-en-1-ylidene]cyclohexane-1,3-diones as minor ones. Endocyclic enamino derivatives were synthesized in two steps through enol methyl ethers which reacted with amines. Endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones containing an aryl group on the nitrogen atom readily underwent cyclization to 1,2,3,4,5,6,7,8-octahydroquinoline-4,5-dione derivatives.

show abstract

mentioning

confidence: 99%

Synthesis of exo- and endocyclic enamino derivatives of 2-(3-arylprop-2-enoyl)cyclohexane-1,3-diones

2011

Self Cite

View full text Add to dashboard Cite

show abstract