Synthesis and Antiproliferative Activity of Diethylamine Mannich Base of Asymmetrical Mono-Carbonyl Curcumin Analogs against HeLa Cell Lines

Abstract

A series of diethylamine Mannich base of asymmetrical mono-carbonyl analogs of 10 curcumin (AMACs) were synthesized and evaluated for cytotoxic activity against Hela Cell lines. 11The structures of the synthesized compounds were confirmed on the basis of FTIR, 1 H-NMR, 1213 C-NMR and mass spectral data. Preliminary cytotoxic test using BSLT showed that all the

Synthesis, Antioxidant, and Anti-inflammatory Activity of Morpholine Mannich base of AMACs ((2E, 6E)-2-({4-hydroxy-3- [morpholin-4-yl-)methyl]phenyl}methylidene)-6-(phenylmethylidene) cyclohexan-1-one) and Its Analogs

“…The asymmetrical mono-carbonyl analogs of curcumin (AMACs) (3a-f) were prepared according to procedures reported by our research group previously (Wiji Prasetyaningrum et al, 2017) (Scheme 1).…”

“…The benzaldehyde (1a-e) was condensed with cyclohexanone (2) in the presence of aqueous alkali to give (2E)-2-(phenylmethylidene) cyclohexan-1-one (2a-e) (Furniss et al, 1989). Condensation of 2a-e with vanillin or p-hydroxybenzaldehyde in addition of diluted HCl/ethanol (1:1) under reflux conditions for 30 min gave asymmetrical mono-carbonyl of curcumin (AMACs) (3a-f) (Wiji Prasetyaningrum et al, 2017). Finally, the Mannich reaction of 3a-f with morpholine and formaldehyde at reflux condition in ethanol afforded the title compounds 4a-f (Geschickter and Meadow, 1969).…”