Synthesis and antiproliferative activity of novel hybrid 3-substituted polyhydroquinoline-fatty acids

Abstract

Synthesis and antiproliferative activity of novel hybrid 3-substituted polyhydroquinoline-fatty acids.

Synthesis and antitumoral activity of novel analogues monastrol–fatty acids against glioma cells

“…In another study, the antiproliferative activities of new fatty acid analogs of polyhydroquinoline (hybrid PHQ-fatty acids) against the glioma cell line were investigated. 28 The fatty compounds were synthesized via the Hantzsch multicomponent protocol from several aldehydes and dimedone. The stearic fatty alkyl PHQ hybrid (2, Fig.…”

“…Over the last few years, many studies have emphasized the significance of such derivatives. 25 Building on our previous antitumoral studies using fatty acid derivatives, [26][27][28][29] this work investigated the antitumoral activity of novel monastrol and oxo-monastrol fatty alkyl C6substituted analogues against malignant rat GBM cells (C6); the compounds were synthesized via Biginelli condensation MCRs using a simple approach catalyzed by nontoxic and free-metal sulfamic acid. In this context, we selected palmitic, stearic, and oleic fatty acid derivatives to evaluate the effects of these slightly different molecular structures.…”

Bio-Oriented Synthesis of Novel Polyhydroquinoline Derivatives as α-Glucosidase Inhibitor for Management of Diabetes

“…13 Among heterocycles, the derivatives of PHQ are more crucial in the nitrogen-containing heterocycles due to their promising pharmacological/biological properties. Moreover, these heterocycles have been reported as vasodilator, 14 antiatherosclerosis, 15 anti-tumor, 16 anti-hyperglycemic, 17 anti-proliferative, 18,19 and antioxidant agents. 20,21 α-Glucosidase is found in the brush border surface of the small intestine, which is the key catabolic enzyme of carbohydrates.…”

Hantzsch Reaction using Copper Nitrate Hydroxide- Containing Mesoporous Silica Nanoparticle with C 3 N 4 Framework as A Novel Powerful and Reusable Catalyst

“…Multicomponent reactions (MCRs) are de ned as attractive and powerful synthetic protocols for producing highly complex molecules and biological signi cance molecules owing to the formation of C-C and C-heteroatom bonds in a one-pot manner through an easy tandem synthetic method with stepe ciency and atom-economy (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Polyhydroquinoline (PHQ) derivatives as a signi cant class of nitrogen heterocycle compounds can be converted into biological compounds, displaying promising pharmaceutical and biological properties, including antitumor, antidiabetic, platelet anti-aggregation, bronchodilator, antibacterial, and neurotropic (11)(12)(13)(14). Thus, the production of PHQ derivatives is of great importance.…”