Synthesis and antiproliferative activity of new D-homo and D-seco androstane derivatives

Savić, Marina P.

doi:10.2298/ns20130319savic

Cited by 2 publications

(2 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…FWHM(Hβ ) potentially depending on projection effects, as parametrized by the inclination-dependent factor f BLR (equ. 7.1), projection-independent mass estimates like polarimetry ( [126], [120], [7]) and X-ray variability ( [104], [106]) are important resources, and have been employed, too. The following methods of BH mass estimation have been applied to radio-loud NLS1 galaxies:…”

Section: Black Hole Massesmentioning

confidence: 99%

Multi-wavelength properties of radio-loud Narrow-line Seyfert 1 galaxies

Komossa

2018

Proceedings of Revisiting Narrow-Line Seyfert 1 Galaxies and Their Place in the Universe — PoS(NLS1-2018)

View full text Add to dashboard Cite

Radio-loud Narrow-line Seyfert 1 (NLS1) galaxies are unique probes of the formation of powerful radio jets at extreme (near-Eddington) accretion rates and low black hole masses, in a regime very different from classical blazars and, therefore, not probed before. Further, strong thermal and nonthermal components simultaneously present in their spectral energy distributions (SEDs), shed new light on the jet-disk connection at much shorter timescales, given their low SMBH masses. While NLS1 galaxies have been studied thoroughly at optical and X-ray energies for decades, the populations of radio-loud, and γ-ray emitting NLS1 galaxies have only emerged more recently. This contribution provides a short review of the multi-wavelength properties of this intriguing class of Active Galactic Nuclei (AGN), including X-ray variability and emission mechanisms, γ-ray discoveries, SEDs, star formation activity, host galaxy morphologies, different methods of black hole mass estimation, (unexpected) FeII properties, and high-velocity large-scale outflows possibly driven by the radio jet and with a surprisingly pronounced ionization stratification.Revisiting narrow-line Seyfert 1 galaxies and their place in the Universe Radio-loud NLS1 galaxies S. Komossa this then implies accretion at or near the Eddington limit (Fig. 1). NLS1 galaxies are, therefore, rapidly growing their supermassive black holes (SMBHs), and may represent young or re-juvenated AGN ([99]). In the Eigenvector (EV) analysis of [18], the Eddington ratio L bol /L Edd drives the first eigenvector EV1, while accretion rate drives EV2.While NLS1 galaxies are on average more radio-quiet than broad-line AGN, a fraction of NLS1s are beamed and radio-loud, are highly variable at radio frequencies, and are detected at γ-rays. This contribution provides a review of the multi-wavelength properties of this remarkable new class of radio-loud, jet-emitting AGN.

show abstract

Section: Black Hole Massesmentioning

confidence: 99%

Multi-wavelength properties of radio-loud Narrow-line Seyfert 1 galaxies

Komossa

2018

Proceedings of Revisiting Narrow-Line Seyfert 1 Galaxies and Their Place in the Universe — PoS(NLS1-2018)

View full text Add to dashboard Cite

show abstract

“…[7][8][9] Later, Savic et al showed that partial knockdown of Tcf7l2 results in metabolic phenotypes of smaller body weights, decreased fasting glucose, and improved glucose tolerance in mice. 10 We have published similar observations in mice with the genetic haploinsufficiency of Tcf7l2. 11 However, the role of TCF7L2 in maintaining metabolic homeostasis in specific tissues remains controversial.…”

Section: Introductionmentioning

confidence: 56%

Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice

Obianom

et al. 2019

J. Med. Chem.

View full text Add to dashboard Cite

Wnt/β-catenin signaling pathway is implicated in the etiology and progression of metabolic disorders. While lines of genetic evidence suggest that blockage of this pathway yields favorable outcomes in treating such ailments, few inhibitors have been used to validate the promising genetic findings. Here, we synthesized and characterized a novel class of triazole-based Wnt/βcatenin signaling inhibitors, and assessed their effects on energy metabolism. One of the top inhibitors, compound 3a, promoted Axin stabilization, which led to the proteasome degradation of β-catenin and subsequent inhibition of the Wnt/β-catenin signaling in cells. Treatment of hepatocytes and high fat diet-fed mice with compound 3a resulted in significantly decreased hepatic lipid accumulation. Moreover, compound 3a improved glucose tolerance of high fat dietfed mice without noticeable toxicity, while downregulating the genes involved in the glucose and fatty acid anabolism. The new inhibitors are expected to be further developed for the treatment of metabolic disorders.

show abstract

Synthesis and antiproliferative activity of new D-homo and D-seco androstane derivatives

Cited by 2 publications

References 74 publications

Multi-wavelength properties of radio-loud Narrow-line Seyfert 1 galaxies

Multi-wavelength properties of radio-loud Narrow-line Seyfert 1 galaxies

Triazole-Based Inhibitors of the Wnt/β-Catenin Signaling Pathway Improve Glucose and Lipid Metabolisms in Diet-Induced Obese Mice

Contact Info

Product

Resources

About