Synthesis and antiproliferative activity of novel limonene derivatives with a substituted thiourea moiety

Abstract

No presente trabalho descrevemos a síntese e a avaliação da atividade antiproliferativa, frente a linhagens de células tumorais humanas, de derivados do R-(+)-limoneno (3-18) contendo uma unidade tiouréia substituída. Os derivados com substituintes arílicos (3-6) exibiram atividade citostática frente a todas linhagens testadas, com inibição de 50% do crescimento celular (GI 50 ) em concentrações na faixa de 2,5 a 24 μmol L -1 . Os compostos 3, 10, 12 e 16 foram os mais ativos, com GI 50 na faixa de 0,41 a 3,0 μmol L -1 , frente a diferentes linhagens celulares. A series of R-(+)-limonene

Antitumor activity of (−)-α-bisabolol-based thiosemicarbazones against human tumor cell lines

“…In continuation of our research on structures endowed with anti-cancer activity derived from the abundant natural products found in Brazilian flora [27,28], we selected (À)-a-bisabolol as a chiral building block to construct thiosemicarbazones because of the inherent reactivity of the double bonds towards acid addition. Also, in an effort to find more active anti-cancer agents we consider (À)-a-bisabolol because itself is known to suppress proliferation of various cancer cells [22,23,29].…”

Synthesis, Characterization and Catalytic Investigation of Novel Polymeric Thiourea

“…Also, after the demetallation step the band in the 600 cm −1 range disappeared. The vibrational mode (both stretching and bending) due to the C-N bond appears at 1328 and 1124 cm −1 in the metal complex of thiourea compounds [33][34][35][36][37][38][39].…”

Synthesis, antibacterial and molecular docking studies of new benzimidazole derivatives

“…These are also promising intermediates in the synthesis of tyrosine derivatives, which are well-known compounds used as Biocidal [16] and enantio-differentiating coupling reagents [17]. Heterocyclic structural unit has a significant place among pharmaceutically important synthetic and natural materials [18], showing powerful antiproliferative action [19]. For these reasons, 1,3,5-triazinane derivatives incorporating thiourea unit may be important in many fields [20].…”