Synthesis and antiproliferative evaluation of 5-oxo and 5-thio derivatives of 1,4-diaryl tetrazoles

Mechanism of antiproliferative action of a new d -secoestrone-triazole derivative in cervical cancer cells and its effect on cancer cell motility

“…Several nonsteroidal triazole derivatives are biologically active, including many that possess antiproliferative and proapoptotic properties [21][22][23][24]. The most frequent positions for substitution of the sterane skeleton are C-2, C-3 and C-17.…”

A convenient synthesis and spectral characterization of novel 5,6-dihydro-4H-tetrazolo-[1,5-a][1,5]benzodiazepine derivatives

“…A great deal of attention owing to the high synthetic potential and the outstanding applications of this class of substances developed as pharmacologically active compounds or drugs. [1][2][3][4][5] Tetrazoles are useful reagents in heterocyclic synthesis and are widely used in ring cleavage/ring closure reactions with electrophilic reagents to form new C-N and N-N bonds. 6 Main synthetic routes for these compounds are published in a wide range of scientific journals.…”

Synthesis, Spectral Analysis, In Vitro Microbiological Evaluation, and Molecular Docking Studies of Some Novel 1-(1-Aryl-1H-tetrazol-5-yl)-2-(piperidin-1-yl)ethanone Derivatives

“…Therefore, N-containing heterocycles are especially considered ‘‘privileged” structures for the synthesis and development of new drugs [4, 5]. Tetrazoles and their derivatives have been reported as antibacterial [6], antiviral [7], herbicidal [8], anti-inflammatory [9], antitumor [10], analgesic [11], and antiproliferative [12] agents. Moreover, tetrazoles are representing an important structural motif in medicinal chemistry.…”