Synthesis and antispasmodic activity of nature identical substituted indanes and analogues

Synthesis of Fern Sesquiterpene Pterosin Z via a Novel Palladium-Catalyzed Route

“…Spectra were obtained on the following instruments: IR, Nicolet 205 FT-IR; UV, Varian CARY 3E UV-vis spectrometer; 1 (E,Z)-6-(2′-Acetoxyethenyl)-2,2,5,7-tetramethylindan-1-one (3). A solution of 2 (synthesized as per Sheridan et al 6 ) (2.4 mmol, 640 mg) in Et 3 N (10 mL) was added to palladium acetate (0.13 mmol, 30 mg), triphenylphosphine (0.27 mmol, 70 mg), and vinyl acetate (5 mmol, 430 mg) in a 25-mL glass ampule. The ampule was sealed and shaken until the mixture was homogenous.…”

N-Cyclopentyl-N-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetamide

“…For details of the pharmacological activity of the title compound, see: Sheridan et al (1990Sheridan et al ( , 1999aSheridan et al ( ,b, 2008; Frankish et al (2004). For ionization characteristics, see: Simplício et al (2004).…”

“…Nivemedone, a nitro-indanone has antiallergenic activity (Buckle et al, 1973) while many simple indanols demonstrate bronchodilatory activity (Heinzelmann et al, 1940). We have demonstrated that indanone derivatives possess smooth muscle relaxant activity and inhibit mediator release (Sheridan et al, 1990(Sheridan et al, , 1999a(Sheridan et al, , 1999bFrankish et al, 2004). In a recent study on bioactivity we evaluated the smooth muscle relaxant activity and mediator release inhibition activities demonstrated by a series of aminoindanones (Simplício et al, 2004;Sheridan et al, 2008).…”

The indane diastereoisomers, PH2 and PH5: divergence between their effects in delayed-type hypersensitivity models and a model of colitis

“…[1,2] Initially, our previous studies were focused on Onychium metabolites with the indane skeleton, which feature in a range of molecules in clinical use and which display significant and diverse biological activity. [3][4][5] We have established that monomeric indanes, related to the fern metabolites [6][7][8] together with synthetic 1,2-coupled dimers [9,10] demonstrate smooth muscle relaxant activity and also inhibited histamine release stimulated by compound 48/80 from rat peritoneal mast cells. Initially, we considered this class of compounds, which demonstrated mast cell stabilisation coupled with bronchodilatory activity, as potential treatments for asthma.…”