Synthesis and Antituberculosis Activity of Thiocarboxamide Derivatives of Schiff Bases

Two biologically active thiophene-3-carboxamide derivatives

“…Most Schiff bases (Pellis & West, 1968;Cohen et al, 1977;Csaszar & Morvay, 1983;Lakshmi et al, 1985) and their thiophene derivatives (El-Maghraby et al, 1984;Dzhurayev et al, 1992;Gewald et al, 1966) possess antibacterial, antitubercular and antifungal activities. Sulfur-containing Schiff bases are particularly effective.…”

6-Methyl-N-(4-methoxyphenyl)-2-[(E)-(4-methylphenyl)methyleneamino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

“…For related literature, see: Gewald et al (1966); Cohen et al (1977); Csaszar & Morvay (1983); Lakshmi et al (1985); Mohan & Saravanan (2003); Dzhurayev et al (1992); Sebnis et al (1999); Anilkumar et al (2005); El-Maghraby, Haroun & Mohamed (1984).…”

“…The title compound (I) was one amongst bicyclic tetrahydropyridinothiophenes (Sebnis et al, 1999), found to exhibit antimicrobial and anti-inflammatory activities. Schiff bases (Csaszar & Morvay, 1983;Lakshmi et al, 1985;Cohen et al, 1977) and their thiophene derivatives (El-Maghraby et al, 1984;Dzhurayev et al, 1992;Gewald et al, 1966) were known for their wide range of biological activities such as antibacterial, antifungal and antitubercular activities. Sulfur containing Schiff bases are particularly effective.…”

N-(3-Chlorophenyl)-2-{[(1E)-(4-methylphenyl)methylene]amino}-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

“…The title compound, C 23 H 21 ClN 2 OS, (I), belongs to a series of 3-arylcarboxamides. The majority of Schiff bases (Csaszar & Morvay, 1983;Lakshmi et al, 1985;Cohen et al, 1977) and their thiophene derivatives (El-Maghraby et al, 1984;Dzhurayev et al, 1992;Gewald et al, 1966) possess antibacterial, antitubercular and antifungal activities. Sulfur-containing Schiff bases are particularly effective (Mohan & Saravanan, 2003).…”