Synthesis and antitumor activities of novel hybrid molecules containing 1,3,4-oxadiazole and 1,3,4-thiadiazole bearing Schiff base moiety

Crystal structure of 5-(adamantan-1-yl)-3-[(2-trifluoromethylanilino)methyl]-2,3-dihydro-1,3,4-oxadiazole-2-thione, C20H22F3N3OS

“…In addition, numerous adamantane derivatives were reported to exhibit marked anticancer [9,10], antibacterial [11][12][13][14] and antifungal [15] activities. 1,3,4-Oxadiazole derivatives were early recognized as a structural motif of particular value in medicinal chemistry [16][17][18], material sciences [19] and agrochemistry [20]. In the present study, we report the structural properties of the title 1,3,4-oxadiazole-N-Mannich base which was reported to exhibit potent antibacterial and marginal antifungal and anti-HIV-1 activity [8].…”

Crystal structure of 2-[3,5-bis(trifluoromethyl)benzylsulfanyl]-5-(5-bromothiophen-2-yl)-1,3,4-oxadiazole, C15H7BrF6N2OS2

“…The uorine atoms of the disorderd CF 3 -group were located on a di erence Fourier map and re ned freely. chemistry as pharmacophores or auxophores possessing diverse pharmacological activities, including antibacterial [1][2][3][4][5], anticancer [6][7][8][9][10], antiviral [11][12][13], antihypertensive [14,15], anti-in ammatory [16,17] and antioxidant [18] activities. In addition, some 1,3,4-oxadiazoles are currently used as safe herbicides for crop protection [19][20][21].…”

Multicomponent One‐pot Synthesis of Oxadiazole Included Pyranopyrazoles as Promising Antioxidant Agents

“…Moreover, the notice of pyranopyrazoles because of numerous series of flavanones and flavones has pyranopyrazole motif base that demonstrated admirable biotic properties . Besides, 1,3,4‐oxadiazoles presence worthy bioisosteres of amides and esters may work together with the receptors by making proton bonding and possibly raise the biotic profile significantly . Several biologically active oxadizoles have been reported previously .…”