Synthesis and Antitumor Activity of Some Novel 5,6,7,8-Tetrahydro- benzo-thieno[2,3-d]pyrimidin-4(3H)-one Derivatives

Abstract

王红梅 a 郭树兵 b 胡扬根 * ,a,c 曾小华 a 杨光义 * ,a,c (a 武当特色中药研究湖北省重点实验室 湖北医药学院医学化学研究所 十堰 442000)

Synthesis of fused tetracyclic benzo[4,5]furo[3,2‐d]pyrimidin‐4(3H)‐ones derivatives containing thiadiazole/oxazolidine/triazole/triazinanone moieties

“…Over the past 10 years, considerable interest has been focused on the strategy to design and synthesize new N‐heterocycle via aza‐Wittig reaction with mild reaction conditions. [ 11–15 ] Herein, we report our efforts aiming to the preparation of fused tetracyclic benzo[4,5]furo[3,2‐d]pyrimidin‐4(3H)‐one derivatives containing 1,3,4‐thiadiazole/1,2,4‐triazole/1,2,4‐triazinanone/oxazolidine moieties via aza‐Wittig reactions.…”

Synthesis of Novel Analogs of Thieno[2,3-d] Pyrimidin-4(3H)-ones as Selective Inhibitors of Cancer Cell Growth

“…In fact, thieno[2,3- d ]pyrimidines with different substituted groups have been prepared and evaluated with regard to pharmaceutical functions, such as 17 beta-hydroxysteroid dehydrogenase inhibition, SIRT2 inhibition, and antimycobacterial and anti-cancer agent effects (Figure 1), etc. [13,14,15,16,17,18,19,20].…”