Synthesis and antitumor activity of 9-(β-aminoethyl)purines

Synthetic Approaches Towards 1,2,4-Triazines Utilizing Wittig and Wittig-Horner Reagents

“…2 Triazine derivatives represent one of these substances, which exhibits biological activities. [3][4][5][6] This, together with our interest in organophosphorus chemistry, 7-13 triggered the synthesis of new organophosphorus compounds incorporating such important nuclei that may possibly lead to biological activity. The present study deals with the reaction of stabilized phosphonium ylides 1a-1c with 5-aroyl-1,2,4-triazinones 2a, 2b and 5-[(hydroxyimino)arylmethyl]-3-phenyl-1,2,4-triazinones 3a, 3b (Figure 1).…”

Five-, Six-, and Seven-membered Lactim Ethers. Methods of Synthesis and Chemical Properties. (Review)

“…Data on the reaction of lactim ethers with various primary amines or their hydrochlorides containing a heterocycle in the molecule are summarized in the schemes below [97,111,[114][115][116][117][118][119][120]. .…”

“…The products 93 [127] and 94 [126] were obtained from lactim ethers and the salts 91 and 92 respectively. It should be noted in conclusion that many of the compounds synthesized by the reactions of lactim ethers with amines exhibit a wide range of biological activity: They are inhibitors of the coagulation of blood [102,[104][105][106][109][110][111][112], exhibit hypoglycemic activity [91, 93-95, 104, 108, 109], antiviral activity [92,93,103], anti-inflammatory activity [104], antitumor activity [119], and antidiabetic activity [92], and have also been recommended as fungicides [87,125,128] or additives that increase the productivity of animals [100].…”