Synthesis and antitumor activity of new isolated and fused heterobicyclic nitrogen systems containing 1,3,4-thiadiazole moiety derived from N1,N2-diaryl hydrazine compound

Abstract

New pyrazolyls and/ or 1,2,4-triazines bearing 1,3,4-thiadiazole moiety (3-10) have been synthesized via an interaction between 2-[5-(2-(4-chlorophenyl)hydrazineyl)-1,3,4-thiadiazol-2-yl]phenol and bi-oxygen/ chloro nitrogen compounds in different conditions. Former structures of the new systems have been established from their elemental and spectral data (FT-IR, 1H/ 13C NMR, Mass spectra). All the obtained compounds were evaluated against MCF7 cell line cytotoxicity and antitumor cells. Compounds 9>10>2>7>8>4>5>6 exhibited important action.