Synthesis and antitumor activity of sacroflavonoside

Abstract

Sacroflavonoside, a new derivative of diphenylethene, was isolated from Artemisia sacrorum, which have been found to possess the inhibitory effect on the proliferation of gastric carcinoma cells (MKN-45) in vitro in our previous studies. With anisaldehyde (SM-A) as starting material, the sacroflavonoside was synthesized by nucleophilic addition, electrophilic substitution and dehydration cyclization. The structure of sacroflavonoside was established by 1D ( 1 H NMR and 13 C NMR) and 2D-NMR (HSQC and HMBC) spectral analysis. The antitumor activity and potential mechanism against MKN-45 cells of sacroflavonoside were evaluated in vitro. The results showed that sacroflavonoside could significantly induce MKN-45 cells apoptosis and autophagy by increasing the expression of Bax, Caspase-3, Beclin1 and LC3-II proteins and decreasing the expression of Bcl-2 protein at low micromole level. This investigation provided a valuable lead structure for the development of antitumor drugs.

Design, Synthesis and Biological Evaluation of C-8 Modified Curcumol Derivatives as Potential Anticancer Agents

“…However, chemotherapy treatment of CRC is not satisfactory in the clinic because of the toxic side effects. Indeed, natural drugs have been a crucial part of anti-cancer drugs, and more than half of the approved anticancer drugs are either natural products or developed on the basis of knowledge gained from natural products [7][8]. Therefore, one feasible approach of seeking new chemotherapy drug candidate from phytochemicals is to modify the current clinically available anti-CRC medicines.…”