Synthesis and Antitumor Activity of Novel 1‐(2′‐Alkyl(or Phenyl)thioethoxy)methyl‐5‐fluorouracils and Their Oxidation Products.

Abstract

Nucleic acids U 0700Synthesis and Antitumor Activity of Novel 1-(2'-Alkyl (or Phenyl)thioethoxy)methyl-5-fluorouracils and Their Oxidation Products. -The novel 5-fluorouracil derivatives (V) and their sulfoxides (VI) and sulfones (VII) are synthesized and screened for their anticancer activities. (Va) and (VIc) exhibit activity against A-549 lung carcinoma cell lines. -(LIU*, X.-J.; CHEN, R.-Y.; BAI, D.-L.; Heteroat.