Synthesis and antitumor activity of a series of osmium(vi) nitrido complexes bearing quinolinolato ligands

Abstract

A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.

Synthesis, crystal structure, cytotoxicity and action mechanism of a Rh(iii) complex with 8-hydroxy-2-methylquinoline as a ligand

“…[16][17][18][19][20] Since 8-hydroxy-quinoline possesses a superior chelating ability towards transition metal ions, a series of transition metal complexes with 8-hydroxy-quinoline and its derivatives as ligands have been synthesized and characterized recently. These complexes include quilamine chelators for FeIJII), 21 glycosylated CuIJII) ionophores as prodrugs for β-glucosidase activation in targeted cancer therapies, 22,23 OsIJVI) complexes, 24 clioquinol CuIJII) and ZnIJII) complexes, 25 hydroxyquinoline-containing complexes, [26][27][28] and RuIJII) complexes. 29,30 Chen and coworkers have reported a series of 8-hydroxy-quinoline metal complexes with high antitumor activity.…”

Development of anticancer agents: wizardry with osmium

“…For example, whereas Ru(III)-DMSO complexes were reduced by natural reducing agents, such as ascorbic acid, the NO compounds were stable for at least 24 and 72 h for ruthenium and osmium complexes, respectively. However, Ru-NO complexes underwent hydrolysis of M-Cl, whereas their osmium counterparts remained intact in the presence of ascorbic acid.High-valent osmium nitrido complexes: from DNA as a target to endoplasmic reticulum stress Although the anticancer activity of osmium complexes in oxidation states 2+, 3+ and 4+ has been investigated for some time, the therapeutic potential of high-valent Os(VI) compounds remained untapped until recently Che et al discovered that complexes based on the Os VI ≡N fragment displayed potent in vitro and in vivo anticancer activity [23][24][25]. Os VI (nitrido) complexes with azole, quinolinolato and tridentate Schiff-base co-ligands were tested for their potency towards different cancer cell lines.…”

Osmium(vi) nitride triggers mitochondria-induced oncosis and apoptosis

“…To date, osmium( vi ) nitrido (Os VI N) complexes bearing monodentate, bidentate and/or tridentate ligands have shown promising cytotoxicity as potential anticancer metallodrugs (Scheme 1). 21–26 These complexes kill cancer cells via the apoptosis pathway. Presumably, a strong N 3− group weakens the trans ligand and constitutes a vacant and/or a labile coordination site for DNA binding.…”