Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist

Zhang, Yan Chun; Zhou, Jing; Wu, Xiao Ming; Pan, Wei

doi:10.1016/j.cclet.2008.11.012

Cited by 6 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, it could be used as a therapeutic agent for the treatment of cancer, bacterial infection, wounds, etc. [ 18 , 19 ]. At ambient condition, NO is a gaseous molecule and highly unstable in the air.…”

Section: Mofs For the Delivery Of Nitric Oxidementioning

confidence: 99%

See 1 more Smart Citation

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Zhang

Qiao

2020

Nanomaterials

View full text Add to dashboard Cite

Metal–organic frameworks (MOFs) comprising metal ions or clusters coordinated to organic ligands have become a class of emerging materials in the field of biomedical research due to their bespoke compositions, highly porous nanostructures, large surface areas, good biocompatibility, etc. So far, many MOFs have been developed for imaging and therapy purposes. The unique porous nanostructures render it possible to adsorb and store various substances, especially for gaseous molecules, which is rather challenging for other types of delivery vectors. In this review, we mainly focus on the recent development of MOFs for controlled release of three gaseous transmitters, namely, nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S). Although these gaseous molecules have been known as air pollutants for a long time, much evidence has been uncovered regarding their important physiological functions as signaling molecules. These signaling molecules could be either physically absorbed onto or covalently linked to MOFs, allowing for the release of loaded signaling molecules in a spontaneous or controlled manner. We highlight the designing concept by selective examples and display their potential applications in many fields such as cancer therapy, wound healing, and anti-inflammation. We hope more effort could be devoted to this emerging fields to develop signaling molecule-releasing MOFs with practical applications.

show abstract

Section: Mofs For the Delivery Of Nitric Oxidementioning

confidence: 99%

“…Nanomaterials 2020, 10, x FOR PEER REVIEW 3 of 14 for the treatment of cancer, bacterial infection, wounds, etc. [18,19]. At ambient condition, NO is a gaseous molecule and highly unstable in the air.…”

Section: Mofs For the Delivery Of Nitric Oxidementioning

confidence: 99%

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Zhang

Qiao

2020

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Inspired by the obtained interesting results from our previous research, in which an NO‐donor moiety connected to a ‘native’ molecule could markedly enhance its therapeutic impact , we designed two series of NO‐releasing benzimidazole hybrids by coupling lead compound 6 (Figure ) which had moderate Ang II antagonism activity, with NO donors via different linkers (Table ). Herein, we would like to report the synthesis and biological evaluation of these novel NO‐releasing benzimidazole derivatives.…”

Section: No‐releasing Benzimidazole Hybridsmentioning

confidence: 99%

Design, Synthesis and Pharmacological Evaluation of Novel NO‐Releasing Benzimidazole Hybrids as Potential Antihypertensive Candidate

Zhang

et al. 2014

Chem Biol Drug Des

View full text Add to dashboard Cite

Two series of novel NO-releasing benzimidazole derivatives (8a-e, 9a-g) were designed and synthesized by coupling nitro ester and furoxan NO-donor moieties with benzimidazole biphenyl skeleton. The NO-releasing assay indicated that all the target compounds had different level of NO-releasing ability. Furthermore, the isolated organ assay (rat aortic strips) was used to evaluate the antagonism of Ang II-induced vasoconstriction ability. It was observed that the pA2 values of compounds 8e and 9e were better than that of lead compound 6. Moreover, the pharmacological investigation showed that the antagonism of Ang II-induced pressure response by oral administration of compound 8e was obviously superior to that of lead compound 6, and comparable to that of the positive control losartan. These results suggested that NO-releasing hybrids may provide a promising approach for the discovery of novel antihypertensive agents.

show abstract

“…One such candidate, nitric oxide (NO), has remarkable properties and unique antitumor mechanisms that make it a particularly intriguing candidate for cancer treatment. [15][16][17][18] Research has shown that high concentrations of NO can induce tumor cell apoptosis and enhance tumor sensitivity to various forms of cancer treatment, including chemotherapy, radiation, and immunotherapy. NO can also reverse chemotherapy resistance, reduce angiogenesis and the metastatic cascade, and inhibit cancer growth.…”

Section: Introductionmentioning

confidence: 99%

Red cell membrane-coating Prussian blue for combined photothermal and NO gas therapy for nasopharyngeal carcinoma

Wang,

Cheng,

Xing

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

Synthesis and antitumor activity of nitric oxide releasing derivatives of AT1 antagonist

Cited by 6 publications

References 12 publications

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Engineering Metal–Organic Frameworks (MOFs) for Controlled Delivery of Physiological Gaseous Transmitters

Design, Synthesis and Pharmacological Evaluation of Novel NO‐Releasing Benzimidazole Hybrids as Potential Antihypertensive Candidate

Red cell membrane-coating Prussian blue for combined photothermal and NO gas therapy for nasopharyngeal carcinoma

Contact Info

Product

Resources

About