Synthesis and antiviral activity evaluation of some new 6-substituted 3-(1-adamantyl)-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles

Synthesis and antiviral activity of novel [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles, [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazines and [1,2,4]triazolo[3,4-b][1,3,4] thiadiazepines

“…Treatment of triazolethione 2 with acetyl-or benzoyl chloride in refluxing dioxane did not afford the bicyclic structure triazolothiadiazoles 7a,b but gave the acetyl-or benzoyl amino derivatives 6a,b respectively. Compounds 6a,b could be smoothly cyclidehydrated by boiling in phosphoryl chloride affording the [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles 7a,b in good yield. It is worthy to note that compound 7a could be obtained, in a rather better yield: (82 %), directly by the reaction of 2 with acetic acid in boiling phosphoryl chloride.…”

“…Recently, it was reported that the [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazoles and [1,2,4]triazolo [3,4-b] [1,3,4]thiadiazines possess antimicrobial activities. 1 Also, 6-substituted 3-(1-adamantyl)-1,2,4-triazolo [3,4-b] [1,3,4]thiadiazoles have been evaluated for their antiviral activity.…”

“…1 Also, 6-substituted 3-(1-adamantyl)-1,2,4-triazolo [3,4-b] [1,3,4]thiadiazoles have been evaluated for their antiviral activity. 2 The [1,2,4]triazoles and [1,3,4]thiadiazoles are known for their broad-spectrum of biological activities and many other uses. [3][4][5][6][7] Moreover, the triazolothiadiazoles substituted in the 3 and 6…”

Synthesis and characterizations of some new tetra thiosemicarbazones and their cyclization reactions; tetra 4-methyl-5-etoxycarbonyl-2,3-dihydro-1,3-thiazole and tetra 2-acetylamino-4-acetyl-4,5-dihydro-1,3,4-thiodiazole derivatives

“…23,24 Besides, 1,3,4-thiadiazoles and 1,3-thiazoles and their derivatives exhibit various biological activities such as antituberculosis, 24 antimicrobial, [25][26][27] anti-inflammatory, [28][29][30] antiviral, anticonvulsant, [31][32] antihypertensive, [33][34] local anesthetic, 35 anticancer, [36][37] hypoglycemic, 38 and cytotoxic activities, among others. [39][40][41][42][43][44][45] 1,3,4-Thiadiazole and related compounds are of great interest in chemistry owing to their bioactivity of certain plant growth regulating effects as well as antimicrobial activity. [46][47][48] Antitubercular activites of thiadiazoles linked with aromatic cycles through the methyleneoxy group have also been reported and compounds of this type have shown inhibition on both cycloxygenase and 5-lipoxygenase activities.…”

Synthesis and antimicrobial activities of some new [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles and [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazines

“…Although there are not many triazoles fused to thiadiazines or thiadiazoles, a number of them are incorporated into a wide variety of therapeutically important compounds possessing a broad spectrum of biological activities. [11][12][13][14][15] In this connection, some biheterocyclic compounds containing two 1,2,4-triazol-3-one rings or both 1,2,4-triazol-3-one and 1,3,4-thiadiazole rings have been synthesized in our laboratory as antimicrobial compounds. 16 In addition, we have obtained some Schiff Base derivatives of the 1,2,4-triazol-3-one ring as antitumor agents, recently.…”