Synthesis and antiviral activity of imidazo[1,2-a]pyridines

Synthesis of 5-amino-N′-(9H-fluoren-9-ylidene)-8-nitro-7-aryl-1,2,3,7-tetrahydroimidazo[1,2-a]pyridine-6-carbohydrazide derivatives based on heterocyclic ketene aminals

“…Imidazopyridines have shown a broad spectrum of pharmacological and biological activities. 1 Among the various derivatives, the imidazo [1,2-a]pyridine framework is likely the most important construction due to its vital role as a key structure in drugs and biologically active compounds with properties such as anti-inammatory, 2,3 antiviral, [4][5][6] antiulcer agents, 7,8 antifungal, 9 anticancer, 10 anxiolytic, 11 anti-ulcer, 12 and antiprotozoal. 13 They are included in marketed drugs such as the clinical anti-ulcer compound zolpidem and alpidem, 14 olprinone, 15 zolimidine, 16 necopidem and saripidem, 17 soraprazan and minodronic acid 18 (Fig.…”

Copper-Promoted Regioselective Intermolecular Diamination of Ynamides: Synthesis of Imidazo[1,2-a]pyridines

“…The imidazo[1,2- a ]pyridine 3 skeleton, a class of nitrogen-containing heterocycles composed of pyridine and imidazole rings, shows numerous biological activities, 4 such as antitumor, antiparasitic, antimicrobial, fungicidal, anti-inflammatory, and hypnotic, and thus is present in several marketed drugs 5 such as alpidem, zolpidem, necopidem, saripidem, zolimidine, and olprinone. Owing to such key pharmacological properties, this moiety has earned significant attention from chemists to develop mild and prolific strategies for its synthesis.…”

Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

“…Imidazo[1,2- a ]pyridine is an important heterocyclic system present in many molecules featuring diverse biological activities, such as antiviral, antimicrobial, antitumor, anti-inflammatory, antiparasitic, hypnotic, etc. [1–5]. It is recognized as a key scaffold due to its broad occurrence in a number of drug candidates and drugs, such as zolpidem [6] ( 1a , used in the treatment of insomnia), and alpidem [6] ( 1b , an anxiolytic agent).…”