Synthesis and Antiviral Activity of New Indole-Based Heterocycles

Abdel‐Gawad, Hassan; Mohamed, Hanan A.; Dawood, Kamal M.; Badria, Farid A.

doi:10.1248/cpb.58.1529

Cited by 69 publications

(22 citation statements)

References 22 publications

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“…Elemental analyses were measured by using a German made Elementarvario LIII CHNS analyzer. Compound 3a [21] and hydrazonoyl halides [22][23][24][25][26][27] 4, 13, and 2b-d [28] were prepared as reported in the literature.…”

Section: Methodsmentioning

confidence: 99%

Synthesis of Certain New Thiazole and 1,3,4‐Thiadiazole Derivatives via the Utility of 3‐Acetylindole

Abdelhamid

Gomha

Kandeel

2016

Journal of Heterocyclic Chem

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2‐(2‐(1‐(1H‐Indol‐3‐yl)ethylidene)‐hydrazinyl)‐4‐substituted 5‐(aryldiazenyl)thiazoles and 5‐((1‐(1H‐indol‐3‐yl)ethylidene)hydrazono)‐2‐substituted‐4‐phenyl‐4,5‐dihydro‐1,3,4‐thiadiazoles were synthesized via reaction of hydrazonoyl halides and 2‐(1‐(1H‐indol‐3‐yl)ethylidene)hydrazine‐1‐carbothioamide and alkyl 2‐(1‐(1H‐indol‐3‐yl)ethylidene)hydrazine‐1‐carbodithioate in ethanolic triethylamine. Structures of the newly synthesis were elucidated on the basis of elemental analysis, spectral data, and alternative synthetic route whenever possible.

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Section: Methodsmentioning

confidence: 99%

Synthesis of Certain New Thiazole and 1,3,4‐Thiadiazole Derivatives via the Utility of 3‐Acetylindole

Abdelhamid

Gomha

Kandeel

2016

Journal of Heterocyclic Chem

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“…Also, 1-[1-(heterocyclic)ethylidene]thiosemicarbazides and their metal complexes have been investigated as potential anticancer agents (Finch et al, 2000;Soares et al, 2012;Serda et al, 2012). On the other hand, ethylidenethiosemicarbazides are reactive building blocks for the construction of bioactive heterocycles, such as: [1,2,3]-thiadiazoles (El-Sadek et al, 2012], imidazolinones (Thanusu et al, 2010), thiazoles (Chimenti et al, 2010;Abdel-Gawad et al, 2010;Vazzana et al, 2004;Vigato & Tamburini, 2004), and thiazolidin-4-ones (Abdel-Gawad et al, 2010). It has been demonstrated that the azomethine group is accountable for biological activities shown by various types of Schiff bases (Vazzana et al, 2004;Vigato & Tamburini, 2004).…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure of a 1,1,2,2-tetrachloroethane-solvated hydrazinecarbothioamide compound

2017

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The title compound, [(1-{4-[2-(2,4-dihydroxyphenyl)diazen-1-yl]phenyl}ethyl-idene)amino]thiourea, 1,1,2,2-tetrachloroethane monosolvate, C 15 H 15 N 5 O 2 SÁ-C 2 H 2 Cl 4 , was prepared from 4-(4-acetylphenyldiazendiyl)resorcinol and thiosemicarbazide and recrystallized from mixed solvents of tetrachloroethane and n-hexane. 1 H NMR and X-ray diffraction data are in support of the thione tautomeric form. The X-ray analysis shows the molecule crystallizes as a zwitterion, with proton transfer from the nominal phenol to the azide group; the N-N bond length is 1.291 (5) Å , and an intramolecular N-HÁ Á ÁO hydrogen bond is formed. In the crystal, N-HÁ Á ÁO, N-HÁ Á ÁN and O-HÁ Á ÁS hydrogen bonds connect the molecules into a three-dimensional network. The tetrachloroethane solvent molecules are linked to this network through weak C-HÁ Á ÁO linkages.

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“…Benzopyrrole, a privileged structure, represents a key motif in heterocyclic chemistry and have shown excellent performances in antibacterial , antiviral , antifungal , inflammatory , antianxiety , and antitubercular activities. Meanwhile, alcohol derivatives are also known to exhibit a wide spectrum biological activities because the group is an important core found in many biologically active compounds with a wide range of biological activity including antibacterial , antifungal , insecticidal , antiviral , herbicidal , anticancer , anti‐HIV‐1 , antihepatitis , antitumor , and anti‐inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Activity of Novel 1H‐indol‐2‐ol Derivatives

Hong

et al. 2017

Journal of Heterocyclic Chem

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A series of novel 1H-indol-2-ol derivatives were synthesized and evaluated their antibacterial activities against rice bacterial leaf blight, tobacco bacterial wilt, and citrus canker caused by Xanthomonas oryzae pv. oryzae (Xoo), Ralstonia solanacearum, and Xanthomonas axonopodis pv. citri via the turbidimeter test in vitro. Antibacterial bioassay indicated that most compounds demonstrated good inhibitory effect against Xoo and Ralstonia solanacearum. Especially, compound 4k demonstrated the best inhibitory effect against Xoo with half-maximal effective concentration (EC 50 ) value of 8.27 μg/mL, which was even better than those of commercial agents Bismerthiazol and Thiodiazole copper.

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Synthesis and Antiviral Activity of New Indole-Based Heterocycles

Abstract: New 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine and 1,3-thiazole derivatives incorporating indole nucleus were prepared using 3-acetylindole as precursor and evaluated for their antiviral activity against herpes simplex type 1 (HSV-1).

Cited by 69 publications

References 22 publications

Synthesis of Certain New Thiazole and 1,3,4‐Thiadiazole Derivatives via the Utility of 3‐Acetylindole

Synthesis of Certain New Thiazole and 1,3,4‐Thiadiazole Derivatives via the Utility of 3‐Acetylindole

Crystal structure of a 1,1,2,2-tetrachloroethane-solvated hydrazinecarbothioamide compound

Synthesis and Antibacterial Activity of Novel 1H‐indol‐2‐ol Derivatives

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