Synthesis and Antiviral Activity of Modified 5α-Steroids

A Search for Sars‐CoV‐2 Main Protease Inhibitors: Synthesis and Docking Study of Steroidal Dinitriles

“…A solution of mixture compounds 7 a and 7 b (1.24 g, 3.35 mmol) in acetone (67 mL) was cooled at 0 °C and CrO 3 in H 2 O (26 mL, 3.5 M, 91 mmol) was added. The mixture was stirred at 0 °C for 30 min and NaCN, DMSO, reflux, 7.5 h 63 [35] 4 NaCN, DMSO, reflux, 10 h 2 4 NaCN, DMF, reflux, 9 h No reaction at room temperature for 24 h. After that reaction mixture was poured into water (300 mL) and extracted with dichloromethane (5×50 mL). After drying and evaporating the organic extract, the crude product was purified by column chromatography (tolueneethyl acetate, 7 : 1) affording 8 in the form of a colorless oil (0.43 g, 32 %).…”

“…It is well known that steroids regulate many physiological processes and thus are involved in the development of a significant number of diseases. However, steroids also display a wide range of biological activities, such as antitumor, antiviral, antibacterial, antimicrobial, antifungal and antioxidant activities, etc [32–36] . Most steroid based pharmaceuticals are semi‐synthetic compounds prepared by modification of a natural steroid which changes their chemical functions and biological specificity.…”