Synthesis and antiviral activity of new 3-methyl-1,5-diphenyl-1H-pyrazole derivatives

Tantawy, A.; Nasr, Magda N.; El‐Sayed, Magda A.‐A.; Tawfik, Samar S.

doi:10.1007/s00044-011-9960-2

Cited by 41 publications

(21 citation statements)

References 15 publications

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“…A new series of 4-substituted 3-methyl-1,5-diphenyl-1 H -pyrazoles ( Figure 38 ) has been synthesized by Tantawy et al and evaluated in vitro for antiviral activity against herpes simplex virus type-1 grown on Vero African green monkey kidney cells through plaque-reduction assay method using acyclovir as a positive control. The results of the antiviral activity of the prepared compounds showed that compound 413 exhibited strong antiviral activity with IC 50 value of 0.02 compared to the used reference drug [ 311 ]. A novel series of bis-pyrazole compounds were synthesized by Zhang et al and tested for anti-viral activity against tobacco mosaic virus (TMV).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review

et al. 2018

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“…Many pyrazole derivatives, including commercially available pharmaceuticals, are known as biologically active compounds. These compounds show a wide range of pharmacological properties such as anti‐inflammatory , anticancer , antibacterial , anti‐viral , antidiabetic , antimicrobial and antifungal activities . Therefore, the oxidative aromatization of pyrazolines, the closest intermediates in the pyrazole syntheses, is in great demand in the preparative strategies of the related pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Efficient Photooxidation of Aryl(hetaryl)pyrazolines by Benzoquinone

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Dolotov

et al. 2019

Photochem & Photobiology

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Photooxidation of aryl(hetaryl)pyrazolines in the presence of benzoquinone has been studied in organic solvents. This reaction occurs at high rate to provide the corresponding pyrazole in a good yield. The effects of the solvent, pyrazoline structure and oxygen provide definite information on the reaction pathway. It appears that radical species are intermediates in the photooxidation of aryl(hetaryl)pyrazolines in the presence of benzoquinone. A comparison of the new results with the photooxidation of aryl(hetaryl)pyrazolines in the presence of perchloroalkanes is also discussed.

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“…These derivatives show broad spectrum activity such as anti-in ammatory [1], anti-oxidant [2], antipyretic [3], antimicrobial [4], antiviral [5], anticancer [6], antitumor [7], anticonvulsant [8], analgesic [9], antidepressant [10], insecticides and fungicides [11,12]. For this title structure, the asymmetric unit contains two independent molecules ( gure).…”

Section: Discussionmentioning

confidence: 99%