Synthesis and antiviral studies of a novel isodideoxynucleoside: an analogue of the antiviral compound, tiazofurin

Nair, Vasu; Wenzel, Thomas J.

doi:10.3998/ark.5550190.0005.e14

Cited by 12 publications

(1 citation statement)

References 5 publications

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“…Tiazofurin is a synthetic nucleoside inhibitor with broad‐spectrum antiviral activity. This drug is a potent inhibitor of IMPDH [44]. As discussed previously, IMPDH is crucial for the synthesis of purine nucleotides.…”

Section: Drugs For the Treatment Of Mpox Virus Infectionmentioning

confidence: 99%

Update on monkeypox virus infection: Focusing current treatment and prevention approaches

Dhapola,

Kumari,

Sharma

et al. 2024

Fundamemntal Clinical Pharma

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BackgroundWhile the world is still facing the global pandemic COVID‐19, another zoonosis monkeypox (Mpox) has emerged posing a great threat to society. Insight into the pathogenesis, symptoms, and management strategies will aid in the development of potent therapeutics for the treatment of monkeypox virus infection.ObjectivesTo get insight into the current treatment and prevention strategies will aid in effectively coping with the disease.MethodsFor obtaining information regarding the ongoing treatment and prevention strategies and the drugs under pipeline, we referred to Google Scholar, Pub Med, Pub Chem, and WHO official site.ResultsThere are a few drugs that came out to be effective for the treatment of Mpox. Tecovirimat acts by inhibiting viral replication and viral wrapping. Another drug is cidofovir, which hinders the activity of viral DNA polymerase but has the drawback of nephrotoxicity. To overcome this, a conjugate of cidofovir is being used—known as brincidofovir—which has a similar mechanism as cidofovir but lesser toxicity. Ribavirin acts via inhibiting inosine monophosphate dehydrogenase (IMPDPH) thus disrupting viral translation. It also interferes with helicase activity. Tiazofurin, Adenosine N1 oxide, and HPMPA have shown efficacy in in‐vitro studies by inhibiting IMPDH, DNA polymerase, and viral mRNA translation respectively. In‐silico studies have proven the effect of nilotinib, simeprevir, and dihydroergotamine for Mpox treatment. They have shown binding affinity for proteins required for the growth and release of MPXV. Vaccines have also been employed for the prevention of Mpox, which includes JYNNEOS, ACAM2000, and VIGIV.ConclusionThis review highlights the pathogenesis of the virus, disease manifestations, drugs, and vaccines that are being used and those under pipeline for the treatment and prevention of Mpox.

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Section: Drugs For the Treatment Of Mpox Virus Infectionmentioning

confidence: 99%

Update on monkeypox virus infection: Focusing current treatment and prevention approaches

Dhapola,

Kumari,

Sharma

et al. 2024

Fundamemntal Clinical Pharma

View full text Add to dashboard Cite

show abstract

Synthesis and antiproliferative activity of two new tiazofurin analogues with 2′-amido functionalities

Popsavin

Torović

Svirčev

et al. 2006

Bioorganic & Medicinal Chemistry Letters

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2-(3-Amino-3-deoxy-β-d-xylofuranosyl)thiazole-4-carboxamide: A new tiazofurin analogue with potent antitumour activity

Popsavin

Spaić

Svirčev

et al. 2006

Bioorganic & Medicinal Chemistry Letters

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Synthesis and antiviral studies of a novel isodideoxynucleoside: an analogue of the antiviral compound, tiazofurin

Abstract: The synthesis and antiviral studies of an isomeric dideoxynucleoside analogue of tiazofurin is described.

Cited by 12 publications

References 5 publications

Update on monkeypox virus infection: Focusing current treatment and prevention approaches

Update on monkeypox virus infection: Focusing current treatment and prevention approaches

Synthesis and antiproliferative activity of two new tiazofurin analogues with 2′-amido functionalities

2-(3-Amino-3-deoxy-β-d-xylofuranosyl)thiazole-4-carboxamide: A new tiazofurin analogue with potent antitumour activity

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