Synthesis and application of chiral monodentate phosphines in asymmetric hydrogenation

Group 6 metal pentacarbonyl complexes of air-stable primary, secondary, and tertiary ferrocenylethylphosphines

“…Crystals of 6c were grown by slow diffusion of hexanes into a concentrated THF solution and crystals of 7a were grown by slow diffusion of pentane into a concentrated 6 | J. Name., 2012, 00, [1][2][3] This journal is © The Royal Society of Chemistry 20xx…”

“…Phosphines, including examples based on ferrocene, 1 are among the most widely exploited L-type ligands within the field of coordination chemistry 2,3 as a result of their tunable steric 4 and electronic 5 properties. They have been employed extensively as ancillary and/or labile ligands in homogeneous catalysts [e.g., Grubbs I 1, Ni(dppp)Cl 2 2, Pd(dppf)Cl 2 3, Wilkinson's catalyst Rh(PPh 3 ) 3 Cl, and Pd(PPh 3 ) 4 ] that rapidly facilitate polymerization, 6 C-C and C-E bond formation, 7 and hydrogenation reactions.…”

Chiral pyridyl phosphinites with large aryl substituents as efficient ligands for the asymmetric iridium-catalyzed hydrogenation of difficult substrates

“…[4][5][6][7] However, the range of olefins that can be hydrogenated with rhodium and ruthenium complexes with high enantiomeric excess is still limited as these catalysts require the presence of a coordinating group next to the C]C bond. With unfunctionalized olefins, they generally show low reactivity and unsatisfactory enantioselectivity.…”

Stereoselective Hydrogenation ofCCBonds: Application to Drug and Natural Product Synthesis

“…61 Monophosphines with axial chirality, e.g., MOP -(2 0 -methoxy-1,1 0 -binaphthyl-2-yl)diphenylphosphine family ligands, 62 and other monodentate binaphthyl-based ligands, as well as diaryl-63 and diheteroaryl-backbone ligands, or similar to them monodentate phosphorus ligands with a spiro scaffold [64][65][66] are widely used for transitionmetal-catalyzed asymmetric C À ÀC bond hydrogenation. [67][68][69] Selected examples of those types of ligands are shown in Figure 29.4.…”