Synthesis and Application of Nanohybrids Based on Upconverting Nanoparticles and Polymers

Cheng, Ziyong; Lin, Jun

doi:10.1002/marc.201400588

Cited by 67 publications

(34 citation statements)

References 356 publications

(557 reference statements)

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“…[ 11,37,88 ] Following this concept, many diverse types of polymers have been employed to render the UCNPs water-dispersible and further providing bioactive chemical moieties for bioconjugation and biofunctionalizations. [ 17,40,89 ] More importantly, polymers can be designed to be light-responsive, which allows the remote release of therapeutic agents. Table 1 lists polymers and their applications that have been explored by different research groups in the fi eld of UCNPs/polymer DDSs.…”

Section: Synthesis Of Ucnp-polymer Compositementioning

confidence: 99%

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

et al. 2016

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The development of drug delivery systems (DDSs) using near infrared (NIR) light and upconversion nanoparticles (UCNPs) has generated intensive interest over the past five years. These NIR‐initiated DDSs not only offer a high degree of spatial and temporal determination of therapeutic release but also provide precise control over the released dosage. Furthermore, these nanoplatforms confer several advantages over conventional light‐based DDSs—NIR offers better tissue penetration depth and a reduced risk of cellular photo‐damage caused by exposure to light at high‐energy wavelengths (e.g., ultraviolet light, <400 nm). The development of DDSs that can be activated by low intensity NIR illumination is highly desirable to avoid exposing living tissues to excessive heat that can limit the in vivo application of these DDSs. This encompasses research in three directions: (i) enhancing the quantum yield of the UCNPs; (ii) incorporation of photo‐responsive materials with red‐shifted absorptions into the UCNPs; and (iii) tuning the UCNPs excitation wavelength. This review focuses on recent advances in the development of NIR‐initiated DDS, with emphasis on the use of photo‐responsive compounds and polymeric materials conjugated onto UCNPs. The challenges that limit UCNPs clinical applications, alongside with the aforementioned techniques that have emerged to overcome these limitations, are highlighted.

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Section: Synthesis Of Ucnp-polymer Compositementioning

confidence: 99%

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

et al. 2016

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“…Photonen‐aufkonvertierende Nanopartikel (UCNPs) wurden in jüngster Zeit als effiziente Vermittler von NIR‐induzierten Photoreaktionen wie Photolysen, Photoisomerisierungen oder Photopolymerisationen verwendet . UCNPs bestehen aus einem Wirt‐Kristallgitter (z.…”

Section: Methodsunclassified

“…Die Synthese und Anwendung der UCNPs und des Pyren‐Aryltetrazols wurden beide kürzlich beschrieben . Um eine effiziente NITEC‐Reaktion zu ermöglichen, muss eine ausreichende Überlappung zwischen der Emission der UCNPs und der Absorption des PAT gegeben sein, die zur Bildung des Nitrilimins führt.…”

Section: Methodsunclassified

Lichtgesteuerte Kupplungsreaktionen im nahen Infrarot mittels Aufkonvertierungs‐Nanopartikeln

et al. 2016

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Wirb erichten über eine Nitrilimin-vermittelte Tetrazol-En-Cycloaddition (NITEC) in Gegenwart von Photonen-aufkonvertierenden Nanopartikeln (UCNPs) als eine effiziente Verknüpfungsmethode.W erden Pyren-Aryltetrazol-Derivate (l abs,max = 346 nm) in Gegenwart von UCNPs mit Nahinfrarotlicht bei 974 nm bestrahlt, so wird das Tetrazol rasch zu einem reaktiven Nitrilimin umgesetzt. In Gegenwart einer elektronenarmen Doppelbindung reagiert das entstandene Nitrilimin unter Umgebungsbedingungen quantitativ zu einem Pyrazolin-Cycloaddukt. Die Kombination von NITEC und UCNP wurde fürC ycloadditionen kleiner Moleküle,P olymer-Endgruppenumwandlungen und die Bildung von Blockcopolymeren aus funktionalisierten Makromolekülen genutzt. Da die Methode vielversprechend fürI n-vivo-Anwendungen ist, wurden Gewebedurchdringungsexperimente in Gegenwart von biologisch relevantem Biotin durchgeführt. Quantitative Cycloadditionen und die Aufrechterhaltung der biologischen Aktivitätd es Biotins unter Bestrahlung bei 974 nm wurden beobachtet.

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“…[1][2][3][4][5][6][7][8][9] In general, lanthanide-doped UCNPs are dilute guest−host systems where trivalent lanthanide ions are dispersed as a guest in an appropriate dielectric host lattice. [1][2][3][4][5][6][7][8][9] In general, lanthanide-doped UCNPs are dilute guest−host systems where trivalent lanthanide ions are dispersed as a guest in an appropriate dielectric host lattice.…”

Section: Doi: 101002/adom201600956mentioning

confidence: 99%

Modulated Visible Light Upconversion for Luminescence Patterns in Liquid Crystal Polymer Networks Loaded with Upconverting Nanoparticles

Teng

Juan

et al. 2017

Advanced Optical Materials

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CommuniCation(1 of 7) 1600956 optical performances of LC systems were achieved only by varying the intensity or wavelength of lasers. [27,28] In their cases, UCNPs were capable of efficiently converting low-energy NIR light to UV or visible radiation, triggering the photoisomerization or photocyclization process of light-driven switches, thereby leading to the pitch change or handedness inversion of helical superstructures. In another representative sample from Yu's group, they developed an NIR light-driven LC polymer actuator, where UCNPs were incorporated into an azotolanecontaining cross-linked LC polymer film. [29] Similarly, the doped UCNPs converted NIR light to UV radiation, triggering the trans-cis photoisomerization of the azotolane units and an alignment change of the LC molecules. As a result, a macroscopic reversible bending deformation was observed accompanied by the NIR light on or off. Based on the above analysis, it is well understood that the UCNPs doped into the LC media can emit UV or visible light under excitation by NIR light that leads to NIR-controlled helical structures of chiral nematic LCs or NIR-driven LC actuators. These processes are referred to as UCNP-assisted controlling of LC orientations in LC materials. However, apart from the polarized luminescence tuning of upconversion nanorod in LC media, [30] almost no attention has been focused on using LC alignment for tuning the luminescence intensity of UCNPs in LC host.In this study, for the first time, we propose a facile but effective strategy to modulate the luminescence intensity of UCNPs in the liquid crystal network (LCN) composite films and further to fabricate upconversion luminescence patterns. The principle is based on the variation of luminescence intensity in an LCN film induced by a change of the LC molecular orientation when applying an electric field. Furthermore, in consideration of the remarkable contrast of luminescence intensity between scattering state and homeotropic state, micro and macrosized upconversion luminescence patterns were fabricated. Here, the luminescence patterns of LCN composite films were obtained by in situ photopolymerization of an LC mixture doped with UCNPs in its scattering and homeotropic oriented states. It is worth noting that the UCNP-doped LCN composite films could withstand higher temperature and more complex ambient environment than lowmolecule-weight LC counterparts or pure UCNP patterns due to the stable crosslinked structure from the LCN, which we believe may be more favorable for practical applications. The strategy demonstrated here offers a convenient and versatile method to regulate the luminescence intensity of UCNPs for fabricating luminescence patterns; it was also believed to provide a new route for emission-based LC display and optical functional films.First, to obtain narrow size distribution, good crystallinity, and high fluorescence efficiency, UCNPs were synthesized

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Synthesis and Application of Nanohybrids Based on Upconverting Nanoparticles and Polymers

Cited by 67 publications

References 356 publications

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

Lanthanide‐Doped Upconversion Nanoparticles: Emerging Intelligent Light‐Activated Drug Delivery Systems

Lichtgesteuerte Kupplungsreaktionen im nahen Infrarot mittels Aufkonvertierungs‐Nanopartikeln

Modulated Visible Light Upconversion for Luminescence Patterns in Liquid Crystal Polymer Networks Loaded with Upconverting Nanoparticles

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