Synthesis and Application of Oligomer with Hydroxy Groups based on Peroxy Derivative of ED-24 Epoxy Resin and PolyTHF-2000 Oligoether

In this study, a series of new1,2,5-oxadiazole compounds derived from 4-chloro-7-nitro-benzo 1,2,5-oxadiazole was synthesized using different organic procedures. The resulting derivatives were chemically characterized and their structures were confirmed by FT-IR and NMR analysis. All the compounds were also evaluated for their antibacterial and antifungal activity against four types of pathogenic bacteria: S.aureus, S.epidermidis (as gram-negative bacteria), E.coli, Klebsiella spp. (as gram-positive bacteria) and the fungus Candida albicans using the agar well diffusion method. The synthesized oxadiazole derivatives exhibited significant antibacterial and moderate antifungal activities. Exploring the binding between the potent synthesized derivative 8 within the active site of glucosamine-6-phosphate synthase, the target enzyme for the antimicrobial agents was achieved using Autodock 4.2 package. The interaction modes of the generated conformers inside the binding pocket were found to enhance the in vitro results, and strongly recommended the new derivatives as promising antimicrobial agents.

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, Antimicrobial and Molecular Docking Study of Benzooxadiazole Derivatives

Naji¹,

Abdula²,

Nief³

et al. 2022

“…The reason is their advantages over other polymers such as easiness during products formation and good operational characteristics of the final products [6]. For many years the researches regarding the creation of ER based oligomers with various functional groups [7][8][9][10][11][12] have been conducted at Lviv Polytechnic National University (Ukraine).…”

Section: Introductionmentioning

confidence: 99%

Influence of Polymer-Silicate Nucleator on the Structure and Properties of Polyamide 6

Levytskyi¹,

Masyuk²,

Katruk³

et al. 2020

Physico-chemical properties of developed nickel-containing modified silicate materials as the nucleators for composites based on polyamide 6 are presented. As it was established, additive of the nucleator modified by polyvinylpyrrolidone promotes the increase of crystallinity degree of polyamide 6 and the decrease of crystallite size. It was found that changes in the structure of the material cause the increase of its tensile strength, surface hardness and Vicat softening point.

“…Recently the researches of the Department of Petroleum Chemistry and Technology (Lviv Polytechnic National University, Lviv Ukraine) carried out chemical modification of epoxy resins by unsaturated [6] and saturated acids [7], glycols [8,9], hydroperoxides [10]. The modified epoxy compounds contain free epoxy and other functional groups, namely carboxy, primary hydroxy, peroxy, acrylate fragment.…”

Section: Introductionmentioning

confidence: 99%

Crosslinking of Epoxy-Oligoesteric Mixtures in the Presence of Dioxydiphenylpropane Diglycidyl Ether Modified With Adipic Acid

Bratychak¹,

Zubal²,

Bashta³

et al. 2017

Self Cite

1 Crosslinking of epoxy-oligoesteric mixtures composed of ED-20 dianic epoxy resin and TGM-3 oligoesteracrylate has been studied in the presence of dioxydiphenylpropane diglycidyl ether modified with adipic acid (DCDER). Crosslinking was carried out at room temperature and while heating at 383, 403 or 423 K using polyethylene polyamine as a hardener. The procedure of DCDER synthesis has been developed. The structural changes were controlled by determining film hardness and gel-fraction content. The chemistry of films formation was confirmed by IR-spectroscopy.Molecular mass (M n ) of the initial and synthesized products was determined using cryoscopy in dioxane [11].