Synthesis and Application of Reactive Polymers via
            <scp>RAFT</scp>
            Polymerization

Gauthier-Jaques, Martin; Mutlu, Hatice; Gaballa, Heba; Théato, Patrick

doi:10.1002/9783527821358.ch18

“…Nevertheless, the functional substrates associated with these chemistries can present several limitations when incorporated as multiple pendant moieties along the polymer chain. Some limitations are the limited compatibility with a wide range of polymerization mechanisms, [23][24][25][26] the pronounced effect on the bulk polymer properties of some of these functional groups, and the custom synthesis of specialized monomers to tailor the polymer substrate to the respective reaction. [27,28] A noteworthy exception is the use of polymers synthesized from activated ester monomers featuring N-hydroxysuccinimide (NHS), nitrophenolate or plurifluorophenolate esters.…”

Section: Introductionmentioning

confidence: 99%

Non‐activated Esters as Reactive Handles in Direct Post‐Polymerization Modification

Guyse

¹

,

Bernhard

²

,

Podevyn

³

et al. 2023

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Non‐activated esters are prominently featured functional groups in polymer science, as ester functional monomers display great structural diversity and excellent compatibility with a wide range of polymerization mechanisms. Yet, their direct use as a reactive handle in post‐polymerization modification has been typically avoided due to their low reactivity, which impairs the quantitative conversion typically desired in post‐polymerization modification reactions. While activated ester approaches are a well‐established alternative, the modification of non‐activated esters remains a synthetic and economically valuable opportunity. In this review, we discuss past and recent efforts in the utilization of non‐activated ester groups as a reactive handle to facilitate transesterification and aminolysis/amidation reactions, and the potential of the developed methodologies in the context of macromolecular engineering.

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Trithiocarbonates in RAFT Polymerization

Moad¹

2021

RAFT Polymerization

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Non‐activated Esters as Reactive Handles in Direct Post‐Polymerization Modification

Guyse

¹

,

Bernhard

²

,

Podevyn

³

et al. 2023

View full text Add to dashboard Cite

Non‐activated esters are prominently featured functional groups in polymer science, as ester functional monomers display great structural diversity and excellent compatibility with a wide range of polymerization mechanisms. Yet, their direct use as a reactive handle in post‐polymerization modification has been typically avoided due to their low reactivity, which impairs the quantitative conversion typically desired in post‐polymerization modification reactions. While activated ester approaches are a well‐established alternative, the modification of non‐activated esters remains a synthetic and economically valuable opportunity. In this review, we discuss past and recent efforts in the utilization of non‐activated ester groups as a reactive handle to facilitate transesterification and aminolysis/amidation reactions, and the potential of the developed methodologies in the context of macromolecular engineering.

show abstract

Synthesis and Application of Reactive Polymers via RAFT Polymerization

Cited by 4 publications

References 96 publications

Non‐activated Esters as Reactive Handles in Direct Post‐Polymerization Modification

Non‐activated Esters as Reactive Handles in Direct Post‐Polymerization Modification

Trithiocarbonates in RAFT Polymerization

Non‐activated Esters as Reactive Handles in Direct Post‐Polymerization Modification

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