Synthesis and Application of ZIF‐8 MOF Incorporated in a TiO₂@Chitosan Nanocomposite as a Strong Nanocarrier for the Drug Delivery of Acyclovir

Abstract

Recently, metal‐organic frameworks (MOFs) have been effectively established as potential nanocarriers for the drug delivery. In this study, we have examined a novel framework containing TiO2@Chitosan@ZIF‐8 for the delivery of acyclovir (ACV). The structure elucidation and physicochemical characterization of the prepared nanocarrier were investigated by various spectroscopic techniques such as Fourier‐transform infrared spectroscopy (FT‐IR), ultraviolet‐visible spectroscopy (UV‐Vis), energy‐dispersive X‐ray spectroscopy (EDX), X‐ray diffraction (XRD), field emission scanning electron microscopy (FE‐SEM), brunauer‐emmett‐teller (BET), and thermal gravimetric analysis (TGA). The obtained results demonstrated that 90 % of the acyclovir was loaded on the TiO2@Chitosan@ZIF‐8 framework. The drug release study was performed in PBS (phosphate buffer saline, pH:7.4) and AB (acetate buffer, pH:5) solutions, which showed 78 % and 82 % release within 3 days.

Preparation of NiFe2O4@MIL-101(Fe)/GO as a novel nanocarrier and investigation of its antimicrobial properties

“…Considering the significance of the previous research related to the need of new drug delivery systems to find a suitable and practical nanocarrier, 36–38 herein, we were able to report a novel magnetic nanocomposite including NiFe 2 O 4 @MIL-101(Fe)/GO, as a carrier for the drug delivery of TC (Scheme 1). Moreover, the antibacterial properties of NiFe 2 O 4 @MIL-101(Fe)/GO, pure TC and the drug-loaded nanocarrier were compared against Escherichia coli and Staphylococcus aureus bacteria by agar well diffusion and MIC methods which showed significant results.…”

Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery

“…As illustrated, the stretching vibrations due to Mg–O and Fe–O in MgFe 2 O 4 NPs are appeared at 435 and 575 cm −1 . Moreover, the main absorption bonds in ZIF-8 structure are appeared at 2925, 1589 and 485 cm −1 due to stretching vibrations of C−H, C=N and Zn–N bonds, respectively 26 .…”

Dissolution and Biological Assessment of Cancer-Targeting Nano-ZIF-8 in Zebrafish Embryos

“…Indeed, these findings are in agreement with those reported in the literature. 45,46 Cancer-targeting GEM⊂RGD@nZIF-8 is responsible for elevating cancer outcomes at the cellular level including uptake, cytotoxicity, and apoptosis. 16 Following these outcomes, cancer-targeting GEM⊂RGD@nZIF-8 was studied further to gain deeper insight into the biological effects of its use in healthy small organisms.…”

“…From these kinetic studies, GEM is proposed to be released from the nZIF-8’s framework by the drug leaching through the pore openings upon dissociation of the nZIF-8 framework in acidic media. Indeed, these findings are in agreement with those reported in the literature. , …”