Synthesis and applications of bicyclic sugar modified locked nucleic acids: A review

Total Synthesis of Nikkomycin Sz and Nikkomycin Soz

“…Meanwhile, inspired by the locked confirmation, scientists designed and synthesized locked nucleic acids and further used them in antisense oligonucleotide (ASO) drugs to treat various diseases (Figure b). Thus, the total synthesis of these locked nucleoside natural products can provide more candidates for new antibiotics and monomers for ASO drug discovery …”

Chemoenzymatic Synthesis of arabino-Configured Bicyclic Nucleosides

“…[14][15][16] Conformationally restricted nucleoside analogues with reduced conformational flexibility constituted a major class of these modified nucleosides. 17 The restriction in the conformation of nucleosides was introduced at sugar moiety, either in the form of locked nucleosides [18][19][20] or spironucleosides [21][22][23] and nucleosides connecting sugar and base moieties. 24,25 The first total synthesis of naturally occurring herbicidal spironucleosides by Mio and co-workers 26,27 in 1991 drew the attention of organic chemists towards the synthesis of modified spironucleosides.…”