Synthesis and Applications ofP–R_f‐Containing Molecules

Zn-Mediated Scalable Synthesis of Trifluoromethylphosphines from Phosphine Chlorides and CF3Br

“…Most studies focus on alkyl, electron-neutral, -rich, or -withdrawing aromatic rings with respect to the electronic properties. Due to the high electronegativity of the trifluoromethyl group, trifluoromethylphosphines (TFMPhos) are weaker σ-donor and stronger π-acceptor ligands as compared with regular phosphines (Scheme c), which would promote reductive elimination in transition metal catalyzed reactions . For example, Schoenebeck et al reported that 1,2-bis­(bis­(trifluoromethyl)­phosphaneyl)­ethane would greatly promote the reductive elimination of trifluoromethyl and phenyl groups on a Pd­(II) complex (Scheme c), a process of which is very challenging for other regular ligands .…”