Synthesis and assessment of drug-eluting microspheres for transcatheter arterial chemoembolization

Du, Lingran; Huang, Yugang; Zhang, Qiang; Zhou, Yi; Huang, Jian‐Wen; Yan, Libiao; Yu, Zongjun; Qin, Aiping; Yang, Hainan; Chen, Mianrong; Liang, Lu; Bian, Biyun; Li, Xufeng; Fu, Jijun

doi:10.1016/j.actbio.2019.02.035

Cited by 22 publications

(7 citation statements)

References 32 publications

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“…This is because, for the microsphere with the same size, the number and density of binding sites are the same, higher drug concentration accompanying more drug molecules requires more time for completion of drug loading, resulting in a slower encapsulation rate and longer time for equilibrium drug loading. [52] Figure 8 shows the drug elution behavior of PASP-AMA 0.30 microspheres loaded with different amounts (55, 90, and 120 mg g −1 ) of DOX•HCl in saline. The three samples showed similar releasing trends which can be divided into two stages (Figure 8a).…”

Section: Drug-loading Kinetics Of the Microspheresmentioning

confidence: 99%

“…This can be explained by the fact that the drug release is controlled by the ion exchange mechanism. [52,53] Thus, once the microspheres were exposed to the ion-rich saline solution, the drugs bound on the surface layer of the microspheres were easily replaced by the cations in the medium, and quickly released into the medium, yielding burst release phenomenon. After that, the cations in the medium continuously and slowly penetrated the interior of the microsphere to exchange the bound DOX•HCl, resulting in its slow and continuous diffusion into the medium.…”

Section: Drug-loading Kinetics Of the Microspheresmentioning

confidence: 99%

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Monodisperse Polyaspartic Acid Derivative Microspheres for Potential Tumor Embolization Therapy

Xu,

Sun,

Guo

2024

Macromolecular Bioscience

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Polyaspartic acid derivatives are a well‐known kind of polypeptide with good biocompatibility and biodegradability, and thus have been widely used as biomedical materials, including drug‐loaded nano‐scale micelles or macroscopic hydrogels. In this work, for the first time, monodisperse polyaspartic acid derivative microspheres with diameter ranging from 120 to 350 µm for potential tumor embolization therapy are successfully prepared by single emulsion droplet microfluidic technique. The obtained microsphere shows fast cationic anticancer drug doxorubicin hydrochloride loading kinetics with high loading capacity, which is much better than those of the commercial ones. Additionally, drug release behaviors of the drug‐loaded microspheres with different diameters in different media are also studied and discussed in detail. These results provide some new insights for the preparation and potential application of polyaspartic acid derivative‐based monodisperse microspheres, especially for their potential application as embolic agent.

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Section: Drug-loading Kinetics Of the Microspheresmentioning

confidence: 99%

Section: Drug-loading Kinetics Of the Microspheresmentioning

confidence: 99%

Monodisperse Polyaspartic Acid Derivative Microspheres for Potential Tumor Embolization Therapy

Xu,

Sun,

Guo

2024

Macromolecular Bioscience

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“…8 Recently, with the increasing demand in clinical, the study of degradable microspheres has become a hot topic. 1 For example, gelatin sponge particles, poly(ethylene glycol) methacrylate (PEGMA) hydrolyzable microspheres, and polysaccharides microspheres combine a Institute of Smart Biomedical Materials, School of Materials Science and with the functions of radiopaque, 9 drug delivery, 10 and on-demand degradable 11 were studied. The size and size distribution of microspheres are critical factors when treating different diseases with embolization.…”

Section: Introductionmentioning

confidence: 99%

The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization

Sun

Shen

et al. 2022

J. Mater. Chem. B

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“…Over the previous few years, there has been increasing interest in the radiolucent permeability of embolic agents, and the problem of nonvisibility can be addressed to some extent by way of bodily mixing the embolic agent with an iodinated contrast agent and injecting it into the target artery. 4 However, the principal dangers of this approach consist of numerous aspects. First, the contrast agent can effortlessly separate from the embolic agent, leading to blurred imaging and misdiagnosis.…”

mentioning

confidence: 99%

“…The properties of the embolic agent play an important part in the property of TAE treatment. Over the previous few years, there has been increasing interest in the radiolucent permeability of embolic agents, and the problem of nonvisibility can be addressed to some extent by way of bodily mixing the embolic agent with an iodinated contrast agent and injecting it into the target artery . However, the principal dangers of this approach consist of numerous aspects.…”

mentioning

confidence: 99%

Two-in-One Visual Gelatin Embolization Microspheres for Precise Localization and Rapid Embolization Studies

Gao

Han

Rafiq

et al. 2023

ACS Materials Lett.

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Transcatheter arterial embolization (TAE) has played a huge role in interventional therapy and tumor embolization of organ hemorrhage and accidental hemorrhage. The selection of embolic materials with better biocompatibility is an important part of TAE. In this work, we prepared a gelatin microspheres (GMs) embolization material that simultaneously encapsulates silver sulfide quantum dots (Ag2S QDs) and barium sulfate (BaSO4), giving it good near-infrared second region (NIR-II) imaging and X-ray imaging effects, while luminescence effect of NIR-II is better than that of X-ray, which breaks the limitation of traditional embolization microspheres with only X-ray imaging. In order to improve the therapeutic effect on tumors, we loaded doxorubicin (DOX) antitumor drugs inside the microspheres and bound thrombin on the surface of the microspheres. Thereby, not only can it help achieve rapid embolization during hemostasis, but its sustained release can also accelerate tumor necrosis. The microspheres have good biocompatibility and blood compatibility. Preliminary application results show that the microspheres can achieve a good embolization effect in the ear artery and renal artery of New Zealand white rabbits. Thus, they can be used as a potential embolization system for drug delivery as well as an effective material for arterial embolization and hemostasis. Significantly, this work realizes the clinical embolization application of NIR-II combined with X-ray multimodal imaging technology in biomedical imaging.

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Synthesis and assessment of drug-eluting microspheres for transcatheter arterial chemoembolization

Cited by 22 publications

References 32 publications

Monodisperse Polyaspartic Acid Derivative Microspheres for Potential Tumor Embolization Therapy

Monodisperse Polyaspartic Acid Derivative Microspheres for Potential Tumor Embolization Therapy

The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization

Two-in-One Visual Gelatin Embolization Microspheres for Precise Localization and Rapid Embolization Studies

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