Synthesis and Bioactivity Evaluation of Acylthiourea Derivatives Based on Isopimaric Acid

Click Synthesis of Triazole-Linked Polyazamacrocycles through Selective Isopimaric Acid Transformations

“…The Supporting Information is available at https://macroheterocycles.isuct.ru/en/mhc200817s. Synthesis (1R,4aR,4bS ,7S ,10 aR)-7-((E)-2-(Methox ycarbonyl) styryl)-1,4a, 7-trimethyl-1,2,3,4,4a,4b,5,6,7,8,10, 3,4,4a,4b,5,6,7,8,10, 3,4,4a,4b,5,6, 7,8,10,10a-dodecahydrophenanthrene-1-carboxamide (6). A solution of compound 4 (0.50 g, 1.18 mmol) in anhydrous CH 2 Cl 2 (10 mL) under a stream of argon was cooled in ice, stirred vigorously for 15 min, and treated with oxalyl chloride (0.70 mL, 8.26 mmol) in CH 2 Cl 2 (10 mL), catalytic amount of DMF (two drops).…”

“…[1] The own biological activity, [2][3][4] low price, and chemical modification potential make this compound to be a valuable raw material for numerous applications. [5][6][7][8][9] So, derivatization of the 4 th position of the isopimarane core with various substituent led to compounds with selective anticancer activity. [6][7][8] Polymerization of isopimaric acid derivatives was carried out to improve the functional properties of polymer products.…”

“…[5][6][7][8][9] So, derivatization of the 4 th position of the isopimarane core with various substituent led to compounds with selective anticancer activity. [6][7][8] Polymerization of isopimaric acid derivatives was carried out to improve the functional properties of polymer products. [9] Despite the wide use Click Synthesis of Triazole-Linked Polyazamacrocycles of another conifer tree resin components (abietic and levopimaric acid derivatives maleopimaric acid) in the synthesis of practically useful macrocyclic compound of several topologies [10][11][12] the macrocyclic derivatives of isopimaric acid were unknown.…”