Synthesis and Bioactivity of 1-((2-Carbamoylguanidino) (furan-2-ylmethyl)urea

Don-Lawson, Dr. Chioma; Nweneka, Daniel Okechukwu; Orie, Kingsley John; Okah, Reminus

doi:10.4236/ajac.2020.117022

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…Furans are convenient intermediates in the synthesis of drugs, such as furosemide 1 , a popular diuretic, and cefuroxime 2 , a penicillin derivative [ 1 ] ( Figure 1 ). Furan compounds are used as anticancer drugs [ 2 , 3 , 4 , 5 ] and serve as a framework for the development of new HIV inhibitors [ 6 , 7 , 8 ], antioxidant [ 9 ] and antibacterial [ 10 , 11 , 12 ] drugs, and agents for the prevention and treatment of diseases associated with estrogen deficiency [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis, E-/Z-Equilibrium in Solution of 3-Hetarylaminomethylidenefuran-2(3H)-ones and the Way to Selective Synthesis of the E-Enamines

2023

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We describe a method to synthesize a new class of hetarylaminomethylidene derivatives of furan-2(3H)-ones. The method uses 5-(4-chlorophenyl)furan-2(3H)-one, triethyl orthoformate, and heterocyclic amines with different ring sizes and heteroatoms under refluxing in absolute isopropyl alcohol. The obtained enamines exist in an equilibrium of E- and Z-isomers, whose configurations relative to the double exocyclic C=C bond were confirmed with a set of NMR spectroscopy data. The E-/Z-equilibrium of the synthesized compounds is affected by the configuration of the intermediate, the volume of its substituents, the site of enolate attack, the presence of intramolecular interactions of amino components, the time of the transformation, the order of mixing of the initial reagents, and the use of polar solvents in the NMR experiment. The advantages of the method are that the reaction time is short, the product yield is high, and product purification is easy.

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Section: Introductionmentioning

confidence: 99%

One-Pot Synthesis, E-/Z-Equilibrium in Solution of 3-Hetarylaminomethylidenefuran-2(3H)-ones and the Way to Selective Synthesis of the E-Enamines

2023

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“…The steps taken in this direction will result in environmentally friendly and green science and technology. Using natural redeemable advanced materials to make polymer composites is a critical step in this direction" [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…a binder and filler used in food, pharmaceutical pills, and other products It has also been used as a reinforcing agent in the manufacture of polymer composites. MCC has also been used as a suspension stabilizer, water retainer, viscosity regulator, and emulsifier in pastes and creams" [7,11,13].…”

Section: Introductionmentioning

confidence: 99%

Microcrystalline Cellulose of Oil Bean Pod: Extraction, Physico-chemical, Brunauer–Emmett–Teller (BET), and Flow-ability Analysis

Nsude

Orie²

2022

AJACR

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Oil bean pods (OBPs) are a biomass that are indiscriminately dumped in eastern Nigeria, thus causes a lot of pollution. In this study, microcrystalline cellulose (MCC) was isolated from oil bean pods using acid hydrolysis, and several characterizations were performed using a variety of sophisticated techniques. Fourier transform infrared (FTIR) spectroscopy analysis has indicated the removal of lignin and hemicellulose from MCC extracted from oil bean pods. Scanning Electron Microscopy and Energy Dispersive X-ray (SEM-EDX) revealed a rough surface and minor agglomeration of the MCC. Furthermore, the isolated MCC has slightly higher inorganic minerals than the raw oil bean pod on the basis of SEM-EDX and the ash content. The Brunauer–Emmett–Teller (BET) analysis reveals that the specific surface area of MCC is 331.94 m2/g, which is greater than that of OBP, with 164.728 m2/g. Other characteristics like pore volume, and average pore diameter or size demonstrate that MCC has a superior property than the raw OBP. This implies that MCC could serve as a better adsorbent than the raw OBP. As a result of the increased surface area and high percentage of MCC, which is associated to chemical treatment of raw OBP, MCC can be used in environmental remediation of heavy metals. The bulk density of MCC was recorded at 0.447, which is slightly above the United States Pharmacopeia (USP) specification of 0.32, and the tapped density was recorded at 0.532. The flow ability of MCC powder determines its suitability as a direct compression binder. Thus, the isolated MCC might be used as a reinforcing element for the production of green composites, binder, adsorbents, and plastic polymers.

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“…The world economic forum recently identified antibiotic resistance as one of the greatest threats to human health [1,2]. Metal complexes have become an emerging tool in drug discovery being widely used as therapeutic compounds to treat several human diseases such as infection, diabetes, anti-inflammatory and neurological disorder [3,4]. A significant interest in the synthesis of metal complex-based drugs with unique research, therapeutic and diagnostic opportunities is currently observed in medicinal organic chemistry.…”

Section: Introductionmentioning

confidence: 99%

“…Among the various 6-membered heterocyclic compounds, aminopyridines have drawn special attention because of the various pharmacological activities associated with the presence of it in targeted molecules. Researchers have shown that the presence of a small molecule of aminopyridine is an advantage for the medicinal properties of the target molecule, whether it is a simple molecule, with just a few groups on it, or is a complicated one, with more heterocycles present in the structure [4,5].…”

Section: Introductionmentioning

confidence: 99%

Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review

Orie¹,

Duru²,

Ngochindo³

2021

AJHC

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Aminopyridines are among the classes of heterocyclic compounds that have been extensively studied in the last few decades owing to their interesting biological activities. They exist in three isomeric forms: 2-aminopyridine, 3-aminopyridine and 4-aminopyridine. The diversity in their pharmacological activities has attracted the attention of many researchers to explore the reasons for their wide potential. This study examines recent advances related to the efficient procedure for synthesizing different types of aminopyridine derivatives, its coordination site with metals and biological activities using systematic literature review and content analysis. Other important concepts of aminopyridines discussed are basicity, electric hindrance as related to percentage yield of isomeric forms and spectra updates on the characterization of aminopyridines. The findings from this study also reveal the array of solvents used for purification processes; ideas on isomers that have not been used in the synthesis of aminopyridine derivatives and their respective biological activities. The significance of this study is on the various synthetic methods revealed, which may be helpful to the development of newer compounds with aminopyridines moieties that could offer high bioactivity and lesser toxicity.

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Synthesis and Bioactivity of 1-((2-Carbamoylguanidino) (furan-2-ylmethyl)urea

Cited by 10 publications

References 15 publications

One-Pot Synthesis, E-/Z-Equilibrium in Solution of 3-Hetarylaminomethylidenefuran-2(3H)-ones and the Way to Selective Synthesis of the E-Enamines

One-Pot Synthesis, E-/Z-Equilibrium in Solution of 3-Hetarylaminomethylidenefuran-2(3H)-ones and the Way to Selective Synthesis of the E-Enamines

Microcrystalline Cellulose of Oil Bean Pod: Extraction, Physico-chemical, Brunauer–Emmett–Teller (BET), and Flow-ability Analysis

Syntheses, Complexation and Biological Activity of Aminopyridines: A Mini-Review

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