Synthesis and bioactivity of a Goralatide analog with antileukemic activity

Li, Zhiliang; Lebedyeva, Iryna; Golubovskaya, Vita M.; Cance, William G.; Alamry, Khalid A.; Faidallah, Hassan M.; Hall, C. Dennis; Katritzky, Alan R.

doi:10.1016/j.bmc.2015.04.061

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…The strain synthesized and secreted metabolites with anticancer and antimicrobial activity (Table 5 ). Li and coworkers [ 57 ] synthesized a goralatide analog with selective anti-leukemic activity against human myeloid HL-60, HEL, Nalm-6 leukemia cells, endothelial HUVEC, glioblastoma U251 and transformed kidney 293T cells. Moreover, a terpene glycoside, Kurilensoside F, with antimicrobial activity [ 58 ] was identified from the excretome of strain MHSD_37.…”

Section: Discussionmentioning

confidence: 99%

In silico biotechnological potential of Bacillus sp. strain MHSD_37 bacterial endophyte

Maumela,

Khwathisi,

Madala

et al. 2024

BMC Genomics

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Background Endophytic bacteria possess a range of unique characteristics that enable them to successfully interact with their host and survive in adverse environments. This study employed in silico analysis to identify genes, from Bacillus sp. strain MHSD_37, with potential biotechnological applications. Results The strain presented several endophytic lifestyle genes which encode for motility, quorum sensing, stress response, desiccation tolerance and root colonisation. The presence of plant growth promoting genes such as those involved in nitrogen fixation, nitrate assimilation, siderophores synthesis, seed germination and promotion of root nodule symbionts, was detected. Strain MHSD_37 also possessed genes involved in insect virulence and evasion of defence system. The genome analysis also identified the presence of genes involved in heavy metal tolerance, xenobiotic resistance, and the synthesis of siderophores involved in heavy metal tolerance. Furthermore, LC-MS analysis of the excretome identified secondary metabolites with biological activities such as anti-cancer, antimicrobial and applications as surfactants. Conclusions Strain MHSD_37 thereby demonstrated potential biotechnological application in bioremediation, biofertilisation and biocontrol. Moreover, the strain presented genes encoding products with potential novel application in bio-nanotechnology and pharmaceuticals.

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Section: Discussionmentioning

confidence: 99%