Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives

Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives

“…Thence, the combination of NO and UA probably protect hepatocytes from inflammation and toxicant-mediated liver damage. On this basis, Chen et al (2011) connected UA with furoxan for a series of novel NOreleasing compounds, which could produce high levels of NO in the liver. Among these NO-releasing compounds, compound 57 showed the best anti-cancer activity against HepG2 cells, with IC 50 values of 3.2 lM.…”

Synthesis and antitumor evaluation of novel hybrids of phenylsulfonylfuroxan and epiandrosterone/dehydroepiandrosterone derivatives

“…The chromatograms were conducted on silica gel (100-200 mesh) and visualized under UV light at 254 and 365 nm. The synthesis of the intermediate 7 from benzenethiol was reported previously in ref [19].…”

Ursolic acid in cancer prevention and treatment: Molecular targets, pharmacokinetics and clinical studies

“…On the other hand, a series of furoxan-based novel nitric oxide-donating ursolic acid derivatives were synthesized and evaluated for their cytotoxicity using the HepG2 cell line. These compounds showed more significant cytotoxic activities than control, 5-fluorouracil and ursolic acid [64]. Tanaka et al [65] demonstrated that derivatization of ursolic acid by oxidation with dioxoruthenium (VI) tetraphenylporphyrins produced compounds that exhibited potent cytotoxic activities against C6 rat glioma and A431 human skin carcinoma cell lines at 10-100 mM compared to parent ursolic acid.…”