Synthesis and biocompatibility of dual-responsive thermosonic injectable organogels based on crosslinked N-(isopropyl acrylamide) for tumour microenvironment targeting

Zardad, Az-Zamakhshariy; Mabrouk, Mostafa; Marimuthu, Thashree; Toit, Lisa C. du; Kumar, Pradeep; Choonara, Yahya E.; Kondiah, Pierre P. D.; Badhe, Ravindra V.; Chejara, Dharmesh R.; Pillay, Viness

doi:10.1016/j.msec.2018.04.059

Cited by 11 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the optimum concentration of drug could be maintained by controlling the release rate of drug. To achieve the desired aims, various materials have been extensively tested such as liposomes [ 4 ], dendrimers [ 5 , 6 ], amphiphilic block copolymers [ 7 , 8 ], hydrogels [ 9 , 10 ] and inorganic‐based nanoparticles [ 2 , 11 , 12 ]. Among numerous drug delivery systems, inorganic‐based nanoparticles have demonstrated extraordinary physical and chemical properties, which make them magnificent drug carriers.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study

Ashour

Mabrouk

Soliman

et al. 2021

IET Nanobiotechnology

View full text Add to dashboard Cite

In the current investigation, mesoporous silica nanoparticles were obtained by various techniques, namely sol-gel (S1), micro-emulsion (S2) and hydrothermal synthesis (S3). The effect of those methods on the final features of the obtained mesoporous silica nanoparticles was studied. The obtained nanoparticles were investigated by TEM, BET surface area, Zetasizer, XRD and FTIR. The preparation method effect was evaluated on the drug release behaviour using doxycycline hyclate as a model drug. In addition, the degree of their compatibility against Saos-2 cell line was also determined. The morphology and microstructure of silica nanoparticles were found to be dependent on the utilised method. Those techniques produced particles with particle sizes of 50, 30-20 and 15 nm and also surface areas of 111.04, 164 and 538.72 m 2 /g, respectively, for S1, S2 and S3. However, different preparation methods showed no remarkable changes for the physical and chemical integrities. The drug release test showed faster release from S2 compared with S1 and S3, which make them more applicable in cases require large doses for short periods. However, the release behaviour of S3 was satisfied for treatments which require long period with relatively highest release rate. The preparation method influenced the cell viability as S1 and S2 showed acceptable cell cytotoxicity compared with S3.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Introductionmentioning

confidence: 99%

Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study

Ashour

Mabrouk

Soliman

et al. 2021

IET Nanobiotechnology

View full text Add to dashboard Cite

show abstract

“…18,19 However, very few biomedical applications of organogels have been reported due to their lack of biocompatibility. 20,21 Based on the nature of the gelling molecules, organogels can be further subdivided into polymeric macromolecules 22,23 or low molecular weight (LMW) organogelators, 24−26 which immobilize the organic solvents by forming a network of either cross-linked or entangled chains for chemical and physical gels, respectively. The easy self-assembly of LMW organogelators was formed by weak interchain interactions such as electrostatic, hydrogen bonding, and van der Waals forces when immersed in organic solvent.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Polyhydroxyalkanoate Organo/Hydrogels

Zhang

Che

et al. 2019

Biomacromolecules

View full text Add to dashboard Cite

Synthetic organogels/hydrogels are attracting growing interests due to their potential applications in biomedical fields, organic electronics, and photovoltaics. Photogelation methods for synthesis of organogels/hydrogels have been shown particularly promising because of the high efficiency and simple synthetic procedures. This study synthesized new biodegradable polyhydroxyalkanoates (PHA)-based organogels/hydrogels via UV photo-cross-linking using unsaturated PHA copolymer poly[(R)-3-hydroxyundecanoate-co-(R)-3-hydroxy-10-undecenoate] (PHU10U) with polyethylene glycol dithiol (PDT) as a photo-crosslinker. The PHU10U was synthesized by an engineered Pseudomonas entomophila and characterized via Fourier transform infrared spectroscopy, 1 H nuclear magnetic resonance (NMR), and 13 C NMR. With decreasing the molar ratio of PHU10U to PDT, both the swelling ratio and pore size were decreased. Meanwhile, increasing densities of the gel networks resulted in a higher compressive modulus. Cell cytotoxicity studies based on the CCK-8 assay on both the PHU10U precursor and PHU10U/PDT hydrogels showed that the novel PHA-based biodegradables acting as hydrogels possess good biocompatibility.

show abstract

“…On-demand drug delivery has drawn a great deal of interest in recent years whether it is for targeted treatment of glioblastomas, delivering local anesthetics, or providing antibiotics . These systems generally fall into two classes: nanomaterials that can be injected locally or systemically based on nanomaterials that are triggered by light or ultrasound or depots that are implanted into a location and, likewise, are generally triggered by light or sound …”

mentioning

confidence: 99%

“…3 These systems generally fall into two classes: nanomaterials that can be injected locally or systemically based on nanomaterials that are triggered by light or ultrasound 4 or depots that are implanted into a location and, likewise, are generally triggered by light or sound. 5 Depot systems can deliver molecules repeatedly in an ondemand fashion over long times. The majority of these depots require implantation, but once implanted can provide ondemand delivery over weeks.…”

mentioning

confidence: 99%

On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules

Menikheim¹,

Leckron²,

Bernstein

et al. 2020

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

While there are a number of nanomaterials that can lead to on demand drug delivery or longterm delivery, there are limited nanotechnologies that are stable for long times, deliver sustained amounts of drugs, and achieve repeated, on demand delivery. We have developed a system based on polyurethane nanocapsules as a platform for long-term and on demand delivery. We synthesized nanocapsules encapsulating either a model drug, fluorescein, or a clinically relevant drug, acriflavine, a HIF-1alpha inhibitor. The nanocapsules were ~250 nm in diameter as measured by DLS and confirmed via SEM, and the molecules were localized in the walls of the nanocapsules as determined by confocal microscopy. Release studies were performed at 37 C in PBS, and both the fluorescein and acriflavine were delivered over several weeks. At the end of the release, no pellet was detectable upon centrifugation of the nanocapsules confirming degradation of the polyurethane shells. The same particles released a fraction of their payload upon the application of either an ultrasonic probe or a clinical grade, ultrasound imaging system used for assessing the retina. The amount of drug released could be tailored by the energy applied to the nanocapsules. One of the most exciting findings beyond being able to tailor how much was released based on the energy applied and the time it was applied was that these nanocapsules could be triggered to release multiple times with at least 10 separate release events triggered for each formulation. Being able to tailor the on-demand release over multiple cycles has the potential to fundamentally change how we can approach delivery of drugs for a variety of applications.

show abstract

Synthesis and biocompatibility of dual-responsive thermosonic injectable organogels based on crosslinked N-(isopropyl acrylamide) for tumour microenvironment targeting

Cited by 11 publications

References 43 publications

Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study

Mesoporous silica nanoparticles prepared by different methods for biomedical applications: Comparative study

Synthesis and Characterization of Polyhydroxyalkanoate Organo/Hydrogels

On-Demand and Long-Term Drug Delivery from Degradable Nanocapsules

Contact Info

Product

Resources

About