Synthesis and Biological Activities of 2-Substituted Benzimidazole-Metal Complexes

Abstract

A series of copper(II) and cobalt(II) coordination compounds with 2-substituted benzimidazole derived monodentate and bidentate ligands have been prepared and characterized by microanalysis, IR and UV-Vis spectroscopy. Synthesized metal complexes have been screened for their in vitro antioxidant and antitumor activity. The complex 4a showed significant nitric oxide free radical scavenging activity (IC 50 65µg/ml), while 3i and 3g showed potent superoxide dismutase activity with IC 50 of 0.26 and 0.28 µM respectively. In vitro cytotoxicity study with human breast MCF-7 and CNS SF 268 cancer cell lines showed that the most active 2-benzyl-1H-benzimidazole Cu(II) complex 3a inhibited the growth of cancer cells at 20 µM concentration.

DNA physical interaction mediated b‐lymphoma treatment offered by tetra benzimidazole‐substituted zinc (ii) phthalocyanine derivative

“…Not only halogenation but also benzimidazoles with metal complexes are observed to have more cytotoxic effects on rhabdosarcoma cell lines . There is a study that reports cobalt and copper substitutions playing a key role in producing anticancer effects against MCF7 and SF268 cancer cell lines . An isomer of heterocyclic molecule (thieno[3,2‐d] [1,2,3] triazolo [1,5‐a] pyrimidines) was synthesized and found to be biologically significant against a panel of cancer cell lines.…”

The medicinal panorama of benzimidazoles and their scaffolds as anticancer and antithrombotic agents: A review

“…Azam et al [58] Demirayak et al [59] prepared some new array of 3-(4-substitutedphenyl)−1-(4-substitutedphenyl)benzo [4,5]imidazo[1,2-a]pyrazine substances (Scheme 5) in the year 2011 under microwave irradiation.…”

“…Azam et al [ 58 ] designed and synthesized an array of copper(II) and cobalt(II) coordination compounds with 2‐substituted benzimidazole‐derived monodentate and bidentate ligands in the year 2009 presented in Scheme 4. Using the trypan blue dye exclusion technique on the MCF‐7 and CNS SF‐268 cancer cell lines, all the synthesized compounds were tested for their in vitro antitumor efficacy.…”