Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Koparır, Metin; Örek, Cahit; Parlak, Akif Evren; Söylemez, A. Ernur; Koparır, Pelin; Karatepe, Mustafa; Daştan, Sevgi Durna

doi:10.1016/j.ejmech.2013.02.025

Cited by 60 publications

(40 citation statements)

References 22 publications

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“…In the current study, we synthesized and characterized by 1 H NMR, 13 C NMR and elemental analyses a new series of Mannich base derivatives containing 1,2,4-triazole moiety.…”

Section: Discussionmentioning

confidence: 99%

“…In the 13 C NMR spectra of thiosemicarbazide derivatives 1a-d the carbon of C¼S group had a typical signal at about 176 ppm and for C¼O group at about 168-180 ppm. Similarly, in the 1,2,4-triazole derivatives 2a-d, the presence of the C¼S group was also confirmed by a signal at about 167-168 ppm and for the C-5 in 1,2,3-triazole system in the range of 154-157 ppm.…”

Section: Chemistrymentioning

confidence: 99%

“…The purity of the synthesized compounds was checked by elemental analyses and thin layer chromatography. The structures of prepared derivatives were determined on the basis of 1 H NMR and 13 C NMR spectra and all of the synthesized compounds have satisfactory analyses for their proposed structures. 1 H NMR spectral results for all compounds together with hydrogen assignments and 13 C NMR spectra results are presented in Experimental Section.…”

Section: Chemistrymentioning

confidence: 99%

“…Our interest was directed to Mannich bases which in recent years have gained importance due to their application in pharmaceutical chemistry and comprehensive bioactivities like antibacterial [10][11][12][13] , antifungal 14,15 , anticancer 16 , analgesic 17 and anticonvulsant 18 properties. They are also used in polymer industry as paints and surface active reagents 19 .…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Popiołek

Rzymowska

Kosikowska

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

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This study presents the synthesis, antiproliferative and antimicrobial evaluation of a new series of Mannich base derivatives containing 1,2,4-triazole system. New compounds were prepared by the reaction of 4,5-disubstituted 1,2,4-triazole-3-thiones with formaldehyde and various amines. The structures of the prepared compounds were confirmed by means of 1 H NMR, 13 C NMR and elemental analyses. Twelve compounds were evaluated for their in vitro antiproliferative activities against six chosen cancer cell lines. All synthesized compounds were screened for their in vitro antimicrobial activity by using the agar dilution technique. For 17 potentially active compounds, their antibacterial activity was confirmed on the basis of MIC (minimal inhibitory concentration) by broth microdilution method using the reference Grampositive and Gram-negative bacterial strains.

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“…In the current study, we synthesized and characterized by 1 H NMR, 13 C NMR and elemental analyses a new series of Mannich base derivatives containing 1,2,4-triazole moiety.…”

Section: Discussionmentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Section: Chemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Popiołek

Rzymowska

Kosikowska

et al. 2014

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

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“…The free radical scavenging activity of all the tested compounds was evaluated according to the method described in the literature 31,32 . The inhibition of all the tested synthesized compounds on (1,1-diphenyl-2-picrylhydrazyl) DPPH free radical by using ascorbic acid (AA) antioxidant agent as positive control in different concentrations are listed in Table 1.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Utility of 4-Aryl-8-arylidene-3, 4, 5, 6, 7, 8-hexa-hydroquinazoline-2-thiol for the Synthesis of Some New Heterocycles as Antioxidant Agents

2017

Chem Sci Trans

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Abstract:The present study deals with the synthesis and reactions of 4-aryl-8-arylidene-3,4,5,6,7,8-hexahydroquinazoline-2-thiol (1). Hydrazinolysis of compound 1 yielded hexahydroquinazolinyl hydrazine 2. Acetylation of compound 2 yielded [1,2,4] triazolo [3,4-b] quinazoline derivative 3. The reaction of compound 2 with diethyl oxalate and ethyl acetoacetate afforded hexahydro quinazolin-2-yl-hydrazinyl-2-oxoacetate 9 and hexahydroquinazolin-2-yl-3-oxobutane hydrazide 10. Treatment of compound 1 with chloroacetyl chloride gave tetrahydro-2H-thiazolo [2,3-b] quinazolin-3(5H)-one 13 which was used as a key for the synthesis of a series of heterocyclic compounds (14-19). The structures of the newly synthesized compounds were elucidated on the basis of elemental analysis, spectral data. The antioxidant activities of some new synthesized compounds have been screened. Compounds 2, 3, 12, 13, 15, 16 and 19 showed antioxidant activity using the DPPH method.

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Synthesis, structural characterization and biological studies of neodymium(III) and samarium(III) complexes with mercaptotriazole Schiff bases

Ain

Pandey

et al. 2015

Applied Organom Chemis

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A series of neodymium(III) and samarium(III) complexes of type [Ln(L)Cl(H 2 O) 3 ] have been synthesized with Schiff bases (LH 2 ) derived from 3-(phenyl/substituted phenyl)-4-amino-5-mercapto-1,2,4-triazoles and isatin. The structures of the complexes were established using elemental analysis, molar conductivities, magnetic moments, infrared, NMR ( 1 H, 13 C) and UV-visible spectra, X-ray diffraction and mass spectrometry. The thermal behaviour of these compounds under non-isothermal conditions was investigated using thermogravimetry and differential thermogravimetry. The intermediates obtained at the end of various thermal decomposition steps were identified from elemental analysis and infrared spectral studies. All the ligands and their complexes were also screened for their antibacterial activity against Staphylococcus aureus and Bacillus subtilis and antifungal activity against Aspergillus niger, Aspergillus flavus and Colletotrichum capsici. The screening results were correlated with the structural features of the compounds.

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Synthesis and biological activities of some novel aminomethyl derivatives of 4-substituted-5-(2-thienyl)-2,4-dihydro-3H-1,2,4-triazole-3-thiones

Cited by 60 publications

References 22 publications

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Synthesis, antiproliferative and antimicrobial activity of new Mannich bases bearing 1,2,4-triazole moiety

Utility of 4-Aryl-8-arylidene-3, 4, 5, 6, 7, 8-hexa-hydroquinazoline-2-thiol for the Synthesis of Some New Heterocycles as Antioxidant Agents

Synthesis, structural characterization and biological studies of neodymium(III) and samarium(III) complexes with mercaptotriazole Schiff bases

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