Synthesis and Biological Activities of Some New Annulated Pyrazolopyranopyrimidines and Their Derivatives Containing Indole Nucleus

Synthesis, Characterization, Solvatochromic Properties, and Antimicrobial‐radical Scavenging Activities of New Diazo Dyes Derived from Pyrazolo[1,5‐a]pyrimidine

“…Of these, heterocycles with pyrimidine molecules represent a continuously expanding field of research in heterocyclic chemistry because of their syntheses, reactions, and biological activities. Pyrimidine structures are seen in numerous pharmaceutical agents and natural products .…”

Applications of pyrazolone in multicomponent reactions for the synthesis of dihydropyrano[2,3-c]pyrazoles and spiro-pyrano[2,3-c]pyrazoles in an aqueous medium

“…32,33,34 As a consequence of this, derivatization of other complex molecules from pyrazolone structure in an aqueous medium for providing enhanced reactivity and activities has emerged. Dihydropyrano [2,3-c]pyrazole and spiro[indoline-3,4pyrano [2,3-c]pyrazoles] are the type of those compounds which are synthesized from pyrazolone over the last decades and holds huge potential in the field of medicinal chemistry because of their wide-ranging biological activities such as-anti-bacterial (J), 35 anti-HIV, 36 insecticidal, anti-infective, 37 anti-platelet, anti-fungal (M), 38,39 anti-cancer (N), 40,41 anti-microbial (K), 42 antioxidant activity (O), 43 molluscicidal agent (P), 44 analgesics, 45 antiinflammatory (Q) 46,47 and it also serves as potential inhibitors of human Chk1 kinase (L) (Figure 2). 48,49 In view of these importances, a vast array of synthetic approaches has been reported over the last decades for the synthesis of dihydropyrano [2,3-c]pyrazole and spiro[indoline-3,4-pyrano [2,3-c]pyrazole] derivatives by employing conventional as well as green method involving two-component, three-component, four-component reactions.…”

Synthesis, Characterization, and Screening for Anti‐inflammatory and Antimicrobial Activity of Novel Indolyl Chalcone Derivatives

“…Heterocyclic compounds containing nitrogen have been described for their biological activity against various microorganisms. The indole unit is the key building block for a variety of compounds, which have crucial roles in the functions of biologically important molecules Introduction of different groups to the modified indole structure can produce a series of compounds with multiple activities. Various 3‐substituted indoles had been used as starting materials for the synthesis of a number of alkaloids, agrochemicals, pharmaceuticals, and perfumes.…”