Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Marinova, Petja Emilova; Tamahkyarova, Kristina Dimova

doi:10.3390/compounds4010010

Cited by 3 publications

(2 citation statements)

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“…Similarly, Masoud et al delved into the complexing properties and biological activities of nucleic acids [4]. Meanwhile, recent contributions by Marinova and Tamahkyarova shed light on the synthesis and biological activities of metal complexes involving 2-thiouracil and its derivatives [5]. Furthering the exploration of uracil derivatives, Bomfim et al synthesized Ru(II) complexes with 6-methyl-2-thiouracil as potential antileukemic agents [6].…”

Section: Introductionmentioning

confidence: 99%

“…Furthering the exploration of uracil derivatives, Bomfim et al synthesized Ru(II) complexes with 6-methyl-2-thiouracil as potential antileukemic agents [6]. The biological activities of 2-thiouracil and its metal complexes vary widely, with some being utilized as agents to combat tuberculosis and arthritis, while others exhibit bactericidal and fungicidal properties [3][4][5]7,8].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Antibacterial Studies of a New Au(III) Complex with 6-Methyl-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

Marinova,

Burdzhiev,

Blazheva

et al. 2024

Molbank

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This article describes the synthesis of a new metal complex using 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one. The compound was analyzed using several methods, including determining its melting point and employing UV-Vis, IR, ATR, 1H NMR, HSQC, and Raman spectroscopy for the free ligand. The metal complex was formed by combining aqueous solutions of metal salts with the ligand dissolved in DMSO and water, along with NaOH in a metal-to-ligand-to-base ratio of 1:4:2. The NMR signals of the ligand were assigned using 1H-1H COSY, DEPT-135, HMBC, and HMQC spectra. Furthermore, the compound’s antimicrobial activity against Gram-positive and Gram-negative bacteria, as well as yeasts, was assessed.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis and Antibacterial Studies of a New Au(III) Complex with 6-Methyl-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

Marinova,

Burdzhiev,

Blazheva

et al. 2024

Molbank

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Investigation of the Complexation Activity of 2,4-Dithiouracil with Au(III) and Cu(II) and Biological Activity of the Newly Formed Complexes

Marinova,

Stoitsov,

Burdzhiev

et al. 2024

Applied Sciences

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The goal of this study is to synthesize, determine the structure, and examine the antimicrobial properties of novel Cu(II) and Au(III) complexes of 2,4-dithiouracil and its derivatives. These complexes were obtained by mixing aqueous solutions of the corresponding metal salts with the ligand dissolved in DMSO and aqueous NaOH, using a metal-to-ligand ratio of 1:4:2. The structures of the new compounds were analyzed by melting point determination, microwave plasma atomic emission spectrometry (MP-AES) for Cu and Au, inductively coupled plasma optical emission spectrometry (ICP-OES) for S, attenuated total reflection (ATR), solution and solid-state NMR, and Raman spectroscopy. The data for 2,4-dithiouracil obtained from the 1H NMR, 13C NMR, distortionless enhancement by polarization transfer spectrum (DEPT-135), proton–proton homonuclear correlation spectrum (1H-1H COSY), long-range 1H-13C heteronuclear multiple bond correlation experiment (HMBC), and heteronuclear single quantum coherence spectra (HSQC) aided the interpretation of the NMR data for the gold and copper complexes. Furthermore, the antimicrobial effect of the free ligands and their complexes was assessed against Gram-positive and Gram-negative bacteria, as well as yeasts.

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Investigation of Gallium(III) Complexes with Thiouracil Derivatives: Effects of pH on Coordination and Stability

Skrobanska,

Zabiszak,

Grześkiewicz

et al. 2024

IJMS

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This study explores the formation and properties of new complexes involving gallium(III) and thiouracil derivatives—2-thiouracil (TU), 6-methyl-2-thiouracil (MTU), 6-propyl-2-thiouracil (PTU), 5-carboxy-2-thiouracil (CTU), and 6-methoxymethyl-2-thiouracil (MMTU). Conducted in aqueous solutions at relatively low concentrations, this research enabled the formation of soluble complexes, identified and described here for the first time. The influence of metal-to-ligand ratios on species distribution and their fluorescence properties was examined through potentiometric titration, alongside visible and fluorescence spectroscopy. Stability constants were determined, revealing that coordination mode and complex stability are pH-dependent, and nitrogen, sulfur, and oxygen atoms are involved in higher pH coordination. Additionally, the structure of the ligand 6-methoxymethyl-2-thiouracil was characterized. The findings suggest that these complexes hold potential for future biomedical applications, particularly as antibacterial and anticancer agents, warranting further studies under physiological conditions.

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Synthesis and Biological Activities of Some Metal Complexes of 2-Thiouracil and Its Derivatives: A Review

Cited by 3 publications

References 55 publications

Synthesis and Antibacterial Studies of a New Au(III) Complex with 6-Methyl-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

Synthesis and Antibacterial Studies of a New Au(III) Complex with 6-Methyl-2-Thioxo-2,3-Dihydropyrimidin-4(1H)-One

Investigation of the Complexation Activity of 2,4-Dithiouracil with Au(III) and Cu(II) and Biological Activity of the Newly Formed Complexes

Investigation of Gallium(III) Complexes with Thiouracil Derivatives: Effects of pH on Coordination and Stability

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