Synthesis and Biological Activity of Some Novel 4‐(5‐Mercapto‐1,3,4‐thiadiazol‐2‐yl)‐2‐phenyl‐5‐[2‐phenylvinyl]‐2,4‐dihydro‐3H‐1,2,4‐triazol‐3‐one

Abstract

A novel and efficient route have been designed for the synthesis of 4-(5-mercapto-1,3,4-thiadiazol-2-yl)-2-phenyl-5-[2-phenylvinyl]-2,4-dihydro-3H-1,2,4-triazol-3-one. All the synthesized compound were characterized by elemental analysis, IR,1H NMR,13C NMR and mass spectra. All the synthesized products were evaluated for their antibacterial activity againstB. SubtilisandE.Coliand antifungal activity againstA. nigerandC.Albicanrespectively. The results indicate that the present compounds may serve as better fungicides when compared to bactericides. The synthesized compounds have turned to be wonder by possessing antimicrobial properties.