Synthesis and Biological Activity of Novel 5-(Alkylthio)-1,3,4-thiadiazol-2(3H)-thione Derivatives

Synthesis of Novel 6-(3,5-Dimethyl-1H-Pyrazol-1-yl)Pyridazin-3(2H)-One Derivatives and their Preliminary Biological Evaluation

“…This was proved in our earlier work on the basis of 13 C NMR spectra of compounds with similar structures. 32 In contrast to chloro-azines, the reaction of the salt (3) with the quaternary ammonium salts of substituted 1,3,5-triazines occurs at the oxygen atom of the pyridazine ring to form the O-substituted products (7a,b), since in the corresponding IR spectra the absorption of the C=O bond disappears. Hindered internal rotation around the N-heterocycle bond occurs in these compounds and in 1 H and 13 C NMR spectra two signals are observed due to protons of N-methyl groups.…”

Diverse Biological Activities of 1,3,4-Thiadiazole Scaffold

“…Hambardzumyan N.E et al synthesized several thiadiazole derivatives by different schemes and confirmed their structure by IR and NMR. They further evaluated the synthesized compounds for plant growth stimulator using bean seeds and concluded that out of the synthesized compounds, five compounds 59 displayed a 75% increase in plant growth while compound 60 displayed 100% stimulation in growth in comparison with heteroauxin and hence can be considered as a new compound for field research as a plant growth stimulator [74] (Figure 13).…”