Synthesis and biological activity of ammonium alkylthiopropionates

An Improved and Green Preparation of 3-(Alkylthio)propionic Acids

“…In order to prevent the formation of the sulfides 5 and 6, the functionality of the starting compounds was simply interchanged so that 3-mercaptopropionic acid (8) and alkyl halides were used instead. This change also multiplied the variety of commercially available starting materials.…”

“…We believe that sulfide 5 can be formed by the cleavage of the C-S bond in compound 14 [24] forced either by heat or by the attack of the thiolate an- Scheme 3. A possible path for the formation of side products in the microwave-assisted thio-alkylation of mercaptopropionic acid (8).…”

“…They have been used as additives in various applications [1 -6] to improve resistance toward heat [2] and oxidants [3], as well as to increase lubrication [4], antibacterial, and detergent properties [1] of various materials. Derivatives with small molecular masses have also been studied in antiviral [7] and other biological [8] applications as close analogues of cysteine and methionine and, therefore, they are potential starting compounds for drug development studies.…”