Synthesis and Biological Activity of Some Bromophenols and Their Derivatives Including Natural Products

Menzek, Abdullah; Bayrak, Cetin; Taslimi, Parham; Kılınç, Namık; Gülçın, İlhami

doi:10.1002/cbdv.202300469

Cited by 7 publications

(1 citation statement)

References 75 publications

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“…A 50 μL addition of BChI/AChI was also used to start the reaction. At a wavelength of 412 nm, the spectrophotometric activities of these enzymes were assessed (Ellman et al, 2023;(Bayrak et al 2023).…”

Section: Ache/bche Activity Determination and Inhibition Studiesmentioning

confidence: 99%

Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG

DEREBASİ,

BULUT,

ERDEN

et al. 2023

Preprint

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p-coumaric acid (p-CA) is one of the most abundant phenolic compounds in nature and human diet. Probiotic bacteria are microorganisms conferring health benefits on host when administered in adequate amounts. The synbiotic interaction of these two contents, found in gastrointestinal tract, and effect of this interaction on intestines are not known. Thus, this study aimed to investigate synbiotic relationship between p-CA and Lactobacillus acidophilus LA-5 (LA-5), Lacticaseibacillus rhamnosus GG (LGG). They were grown in the presence of different concentrations of p-CA and effects of p-CA on probiotic properties, as well as in vitro effects on AChE and BChE activities were examined. Results indicated p-CA did not negatively affect bacterial growth, but increased auto-aggregation of both probiotics. While p-CA increased co-aggregation of LA-5 and LGG against Escherichia coli, it decreased co-aggregation against Staphylococcus aureus. Probiotics grown with p-CA were more resistant to pepsin. While p-CA increased the resistance of LA-5 to bile salt, it decreased the resistance of LGG. The combinations of bacteria and p-CA efficiently suppressed AChE and BChE with inhibition (%) 11.31-68.06 and 13.47-65.14, respectively. Furthermore, surface analysis was conducted using FTIR to investigate the interaction of p-coumaric acid with LA-5 and LGG, and changes in cell components on the bacterial surface were analyzed. The results, recorded in range of 4000-600 cm⁻¹ with resolution of 4 cm⁻¹, demonstrated that p-CA significantly affected only the phosphate/CH ratio for both bacteria. These results indicate the addition of p-CA to the probiotic growth may enhance the probiotic properties of bacteria.

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Section: Ache/bche Activity Determination and Inhibition Studiesmentioning

confidence: 99%

Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG

DEREBASİ,

BULUT,

ERDEN

et al. 2023

Preprint

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Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination

Nguyen,

Kang,

Luu

et al. 2024

Bulletin Korean Chem Soc

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Halogenation is one of the most important transformations in organic synthesis. Halogenated compounds are employed in many reactions to prepare useful molecules. Many methods have been developed to introduce halogens into different compounds. Visible light‐mediated reactions are the efficient, low‐toxic, and mild‐condition methods applied for various organic chemistry transformations. Remarkably, there has been an increasing development in the application of visible light‐induced halogenation in recent years. Herein, we present a comprehensive summary of halogenation reactions including chlorination, bromination, and iodination under visible light irradiation since 2020.

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New Azo Derivative of β‐Diketones and Its Cu(II), Co(II) Complexes: Synthesis, Theoretical Study and Biological Activity

Tahirli,

Sadeghian,

Aliyeva

et al. 2024

Chemistry & Biodiversity

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The paper is focused on biological activity and theoretical study of the structure and properties of a new azo derivative of β‐diketones and its complexes with some metals. The aim of our work was to study the structure and properties of the newly synthesized compound as well as to theoretically determine the possibility of complex formation with the Cu(II) or Co(II) ions. A compound with the same substituents R1 = R2 = CH3 was chosen for the study. A synthesized azo compound based on 4‐amino antipyrine and its complexes with Cu(II), Co(II) in solution and solid phase is reported. The structures of these compounds have been testified by X‐ray, IR and NMR spectroscopy. The combined experimental and theoretical approach was used. To study the structure and properties of the synthesized compound, as well as its possible complex formation with the Cu(II), quantum‐chemical calculations were carried out the 6‐31G basis set and the electron density functional theory (DFT) method. These 3‐(1‐phenyl‐2,3‐dimethyl‐pyrazolone‐5) azopentadione‐2,4 (PDPA) with Cu(II) and Co(II) complexes had effective inhibition against butyrylcholinesterase and acetylcholinesterase. IC50 values were found as 19.03, 3.64 µM for AChE and 28.47, 8.01 µM for BChE, respectively. Cholinesterase inhibitors work to slow down the acetylcholine's deterioration.

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Synthesis and Biological Activity of Some Bromophenols and Their Derivatives Including Natural Products

Cited by 7 publications

References 75 publications

Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG

Effects of p-coumaric acid on Probiotic Properties of Lactobacillus acidophilus LA-5 and Lacticaseibacillus rhamnosus GG

Recent progress in visible light‐driven halogenation: Chlorination, bromination, and iodination

New Azo Derivative of β‐Diketones and Its Cu(II), Co(II) Complexes: Synthesis, Theoretical Study and Biological Activity

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