Synthesis and biological activity of trinuclear seven-coordinated tin(IV) complexes derived from tridentate ligands and trimesic acid

Abstract

2015): Synthesis and biological activity of trinuclear seven-coordinate tin(IV) complexes derived from tridentate ligands and trimesic acid, Journal of Coordination Chemistry, The synthesis of trinuclear Sn(IV) complexes 5a−h, prepared in a one-pot reaction of 2-amino-4-R-phenol (R = H, Me, Cl, NO 2 ), 2-pyridine-carboxaldehyde, 1,3,5-benzenetricarboxylic acid (trimesic acid, H 3 BTC) and dibutyl-and dioctyltin oxides, is described. These compounds were characterized by elemental analysis, mass spectrometry, IR and multinuclear NMR spectroscopy. The structures of 5a and 5b were also determined by single-crystal X-ray analysis. The trinuclear tin system is formed by bridges through the carboxylate moieties. The metal centers are seven-coordinate and the coordination polyhedron of tin can be depicted as distorted pentagonal-bipyramidal (PBP), where the equatorial plane consists of three oxygens and two nitrogens and the organic groups occupy the axial positions. The work presented here combines the useful properties of Schiff bases and H 3 BTC ligands in formation of organotin(IV) complexes and investigates the likely antioxidant (DPPH and TBARS) and antiinflammatory activity (TPA) of the new substances.

Variation of the Molecular Conformation, Shape, and Cavity Size in Dinuclear Metalla-Macrocycles Containing Hetero-Ditopic Dithiocarbamate–Carboxylate Ligands from a Homologous Series of N-Substituted Amino Acids

“…Diorganotin compounds may affect the immune system on repeated exposure. Dibutyltin compounds may have a corrosive or irritant effect on skin and eyes and may be toxic to reproduction or mutagenic . − …”

“…In coordination-driven self-assembly, , organometallic building blocks are of current interest, since the metal–carbon bond connectivity allows to modify a number of chemically important variables of the metal centers such as the Lewis acidity, oxidation potential, coordination number, and steric bulk, among others. , In this context, organotin-based constructs have become relevant during the past years, and an increasing number of 0D, 1D, 2D, and 3D assemblies is documented in the literature. Of these, the vast majority has been derived from carboxylate and dithiocarbamate-functionalized ligands. − Organotin complexes are of interest further because of their fungicidal, bactericidal, insecticidal, and antitumor activity. − …”

Antimicrobial Effect of Organotin Compounds Derived From Phenolic Schiff Bases

“…The 13 C NMR chemical shifts of these groups were not significant, but several signals of 119 Sn NMR were observed in the range of δ -228.9 to -669.7. These range of resonance signals are acknowledged to hexacoordinated and heptacoordinated metallic centers of tin compounds (Dubey e Singh, 2013;Chans et al, 2015). In this case it is reasonable to conclude that compound 5 is a mixture of monomeric species with the metal centers having both coordination patterns in solution, and even dimeric compounds with the metallic center having distinct coordination centers.…”

“…The 13 C NMR of compound 6 did not show relevant chemical shifts. However, the 119 Sn NMR showed signals in the range of δ -240 to -580 revealing that compound 6 is also a mixture of monomeric species with the metal ion at the center of an octahedral geometry as well as in a pentagonal bipyramidal geometry, probably in a dynamic equilibrium as showed in Figure 6 (Dubey e Singh, 2013;Chans et al, 2015).…”

Three‐dimensional coordination polymers based on trimethyltin cation with nicotinic and isonicotinic acids as anticancer agents

“…Among the many potential applications that can be extrapolated from these properties are gas storage, molecular separation, chemical catalysis, sensing, ion exchange and drug delivery . One of the applications of coordination compounds is their use as anticancer agents . Cancer is still a worldwide health problem, affecting both developing and developed countries.…”