Synthesis and biological activity of new 2,6-diphenyl-4-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridines

Subhashini, N; Reddy, Ch. Bhaskar; Kumar, Pradeep; Lingaiah, B. P. V.

doi:10.1134/s1070363216120483

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…Hydrazones with a sterically accessible -CH 2 moiety (e.g., 21) gave 1,3,4-trialkylpyrazoles 22, while substrates bearing an -CH 3 group and a sterically hindered or no -CH 2 moiety (e.g., 23) led to 1,3-dialkylpyrazole-4carbaldehydes 24 (Scheme 8). 35 In related reports involving the synthesis of biologically active heterocycles utilizing the Vilsmeier-Haack reaction, the synthesis of 2-(2′-(3-(substituted)-4-formyl-2,3-dihydro(pyrazol-1-yl)-6′-(4-chlorophenyl)-6H-1,3-thiazin-4′-yl)-N-phenylacetamide derivatives, 3-(4-n-[4-(4-formyl-1aryl-1H-3-pyrazolyl)phenoxy]alkoxyphenyl)-1-aryl-1H-4pyrazole carbaldehydes 25 and bis-pyrazoles 26 were developed by Jupudi et al 36 and Subhashini et al, 37 respectively (Figure 1). Popov et al developed the highly selective formation of 5-chloropyrazoles.…”

Section: Cluster Synlettmentioning

confidence: 99%

Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis

Singh

Dohi

Kumar

et al. 2023

Synlett

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The Vilsmeier–Haack reaction has historically been a topic of significant interest to organic chemists, and it continues to attract considerable attention. The reaction itself provides a facile route towards a large number of aromatic and heteroaromatic systems. The Vilsmeier–Haack reagent, generated from amides and halides, is found to be very important in organic synthesis. This account highlights recent developments in the synthetic utility of the Vilsmeier–Haack reagent.1 Introduction2 Formylation3 Formylation and Chlorination4 Formylation and Acetylation5 Chlorination6 ortho-Formylation7 Miscellaneous8 Conclusions

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Section: Cluster Synlettmentioning

confidence: 99%

Synthetic Utility of the Vilsmeier–Haack Reagent in Organic Synthesis

Singh

Dohi

Kumar

et al. 2023

Synlett

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“…One‐pot three component reaction of 2‐naphthol, substituted 4‐(1‐phenyl‐1 H ‐[1,2,3]‐triazol‐4‐ylmethoxy)‐benzaldehydes and cyclic 1,3‐diketones in the presence of catalytic amount of iodine gave 12‐[4‐(1‐phenyl‐1 H ‐[1,2,3]‐triazol‐4‐ylmethoxy)‐phenyl]‐8,9,10,12‐tetrahydro‐benzo[a]xanthen‐11‐one derivatives 13 (Scheme ) in excellent yields …”

Section: Conventional (Thermal) Synthesis Of Xanthenonesmentioning

confidence: 99%

Synthesis of Xanthenones: A Review

et al. 2016

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Xanthenones constitute one of the most important classes of the naturally occurring organic compounds produced by many microorganisms. They exhibit many biological activities e. g., antibacterial, analgesics, antipyretics, cofactors etc. Structurally, these are the linear tricyclic compounds usually having O‐heteroatom and carbonyl group. The xanthenone scaffold can be considered as a privileged structure as a lead for the search of new bioactive molecules. Being of pervasive importance, their synthesis by conventional thermal methods has been the subject of many studies. The recent strategies in synthetic organic chemistry concerning the synthesis of novel organic compounds having diverse applications mainly aims at improvement in atom as well as cost efficiency, avoidance of toxic reagents, and reduction in waste. In this context, photochemical reactions are relevant both from economical as well as from ecological point of view and also obey the demands of “green chemistry” or of an “ideal synthesis”. This article presents a review on the synthetic methodologies of the xanthenones‐ thermal (2012 onwards) and photochemical in addition to our own work on their synthesis.

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