Synthesis and biological activity of novel series of heterocyclic compounds containing succinimide moiety

Abstract

In the search for biological agents, a series of new N-substituted ethyl 11-ethyl-7-methyl-3,5,10-trioxo-4-azatricyclo[5.2.2.02,6]undecane-8-carboxylates 3, 9-methyl-3,5,8-trioxo-4-azatricyclo[5.2.1.02,6]dec-1-yl acetates 6 and 1,3-dioxo-4,5,6,7-tetraphenyl-2,3,3a,4,5,7a-hexahydro-1H-isoindole-4-carboxylic acids 9 were prepared. All compounds were characterized by 1H NMR, ESI-MS, and elemental analyses. Moreover, for intermediate products 2, 5, and 8, X-ray structural analyses were conducted. Compounds 3a–e, 6a, 6b, 9a–e were tested for their cytotoxic properties in K562 and HeLa cells.

Kinetic Studies of Newly Patented Aminoalkanol Derivatives with Potential Anticancer Activity as Competitive Inhibitors of Prostate Acid Phosphatase

“…Considering the versatility of acid phosphatase and its influence on many biochemical processes in the human body as well as its diagnostic properties, this study aimed to investigate the characteristics and inhibition type of the new derivatives of 1,7-dimethyl-8,9-diphenyl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5,10-trione (Figure 1) with a potential anticancer activity, which can act as inhibitors of acid phosphatase. The synthesis, chemical characterization, and anticancer activity of the aforementioned compounds (I) and (II) were described previously in a patent application [36].…”

The Solid-State Structures of Cyclic NH Carboximides

“…Twenty structures exhibit a linear ribbon type of hydrogen bonding (C(4)) in pattern B. These are compounds 133 [122], 134 [124], 135 [120], 136 [125], 137 [126], 138 [126], 139 [127], 140 [128], 130 [121], 141 [129], 142 [124], 143 [130,131], 144 [132], 145 [132], 146 [119], 147 [119], 148 [113], 149 [133] and 150 [134] (Figure 45).…”

“…128 [119], 129 [120], 130 [121], 131 [122] and 132 [123] (Figure 44) exist as simple R Twenty structures exhibit a linear ribbon type of hydrogen bonding (C(4)) in pattern B. These are compounds 133 [122], 134 [124], 135 [120], 136 [125], 137 [126], 138 [126], 139 [127], 140 [128], 130 [121], 141 [129], 142 [124], 143 [130,131], 144 [132], 145 [132], 146 [119], 147 [119], 148 [113], 149 [133] and 150 [134] (Figure 45). One structure, compound 151 [135] (Figure 46) exhibits the square hydrogen bonding R 4 4 (16) pattern G involving four molecules.…”

In Vitro and In Silico Kinetic Studies of Patented 1,7-diEthyl and 1,7-diMethyl Aminoalkanol Derivatives as New Inhibitors of Acetylcholinesterase

“…The synthesis, chemical characterization, and anticancer activity of the aforementioned compounds (I), (II), (III) and (IV) were described previously in a patent application [ 37 ]. Toxicity of the studied compounds for chronic myelogenous leukemia cells, K562 and HeLa cells was in the range 400–100 μM [ 37 ].…”