Synthesis and Biological Activity of Some Novel Phenyl Pyrazoline Derivatives

Abstract

A new series of 4-(4-hydroxyphenyl)-3-chloro-1-{4-[5-(substituted phenyl)-1-phenyl-4,5dihydro-pyrazol-3-yl]phenyl}azetidin-2-one were synthesized by reacting 3-chloro-1-{4-[3-(substituted-phenyl)prop-2-enoyl]phenyl}-4-(4-hydroxyphenyl)azetidin-2-one (0.01 M) and phenyl hydrazine (0.01 M) in presence of acetic acid (glacial). All these compounds were characterized by means of their IR, 1 H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.

Thiazole-based aminopyrimidines and N-phenylpyrazolines as potent antimicrobial agents: synthesis and biological evaluation

“…Wave-numbers in the IR spectra are given in cm À1 . 1 H NMR and 13 C NMR spectra of the newly synthesized compounds, in DMSO-d 6 or CDCl 3 solutions, were recorded on a Bruker AC 300 instrument (Bruker, Karlsruhe, Germany) at 298 K. Chemical shis are reported as d (ppm) relative to TMS as an internal standard. Coupling constants J are expressed in Hertz (Center of Instrumental Analysis of the University of Thessaloniki).…”

“…linezolid). [9][10][11] N-Phenylpyrazolines and aminopyrimidines display a broad spectrum of potential pharmacological activities such as antimicrobial, [12][13][14][15] anti-inammatory, 16,17 antileishmanial, 18,19 antidepressant, 20 etc.…”

Acoustic and Thermo-Dynamical Investigation of 2-Amino-5-Nitrothiazole- DMSO-Water System at Different Temperatures and Concentration

“…Heterocyclic molecules have great application in therapeutic chemistry and play key role in development of most of the therapeutic drugs [2]. Hetero atoms containing cyclic compound have wide range of physiological properties i.e., antibacterial, anti-inflammatory, muscle relaxant, lipid peroxidation inhibitor ant tubercular and insecticidal [3][4][5][6][7][8]. In present investigation the heterocyclic compounds use has great importance in life process [9].…”